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J Biol Chem

Title:		Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system
Author(s):		McKenna MP; Hekmat-Scafe DS; Gaines P; Carlson JR;
Address:		"Department of Biology, Yale University, New Haven, Connecticut 06511-8112"
Journal Title:		J Biol Chem
Year:		1994
Volume:		269
Issue:		23
Page Number:		16340 - 16347
DOI:
ISSN/ISBN:		0021-9258 (Print) 0021-9258 (Linking)
Abstract:		"Four genes expressed in the olfactory system of Drosophila melanogaster have been identified by subtractive hybridization. Two of these genes, OS-E and OS-F, are related to genes encoding moth pheromone-binding proteins. The OS-E and OS-F genes are tightly linked and are expressed in a subregion of the antenna (the primary olfactory organ). A protein sequence analysis suggests the possibility that pheromone-binding proteins are members of a larger class of proteins, extending beyond the olfactory system. The predicted product of a third gene, OS-D, shares features common to vertebrate odorant-binding proteins, but has a primary structure unlike odorant-binding proteins. The fourth gene, OS-C, encodes a novel 13-kDa protein that contains a putative nuclear import sequence and an acid-rich region. The expression patterns of these genes differ within the antenna; their transcript distributions support the notion of specialized roles for different olfactory sensilla. The functions of the OS gene products have not been demonstrated; however, the potential identification of pheromone-binding proteins in Drosophila, a species with well characterized genetics, may offer a means of analyzing the function of these molecules that is not available in other systems"
Keywords:		"Amino Acid Sequence Animals Base Sequence Carrier Proteins/genetics Chemoreceptor Cells/*physiology Chromosome Mapping Cloning, Molecular *Drosophila Proteins Drosophila melanogaster/*genetics Genes, Insect/*genetics Genetic Linkage In Situ Hybridization;"
Notes:		"MedlineMcKenna, M P Hekmat-Scafe, D S Gaines, P Carlson, J R eng DC00139/DC/NIDCD NIH HHS/ GM 36862/GM/NIGMS NIH HHS/ MH18397/MH/NIMH NIH HHS/ Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1994/06/10 J Biol Chem. 1994 Jun 10; 269(23):16340-7"