| Title: | Silencing and heritable domains of gene expression |
| Address: | "Department of Molecular and Cell Biology, University of California, Berkley 94720, USA" |
| DOI: | 10.1146/annurev.cb.11.110195.002511 |
| ISSN/ISBN: | 1081-0706 (Print) 1081-0706 (Linking) |
| Abstract: | "Silencing is a process that assembles particular regions of eukaryotic chromosomes into transcriptionally inactive chromatin structures. Silencing involves specialized regulatory sites known as silencers and a combination of general DNA-binding proteins and proteins dedicated to silencing. In the yeast Saccharomyces cerevisiae, these proteins include transcription factors and the origin recognition complex (ORC). Silencing has three recognizably separate phases: establishment, maintenance, and inheritance. At least some silencers are origins of replication, and the establishment of the silenced state requires an S phase-specific event. Once established, the silenced state is heritable, even in the absence of proteins required for its establishment. The silencing of mating-type genes bears many similarities to telomere position effects, and the two processes require many of the same proteins" |
| Keywords: | "Alleles Cell Cycle Chromatin/physiology *DNA Replication Fungal Proteins/genetics/physiology GTP-Binding Proteins *Gene Expression Regulation, Fungal *Genes, Fungal *Genes, Mating Type, Fungal Histones/metabolism Mating Factor Peptides/genetics/physiology;" |
| Notes: | "MedlineLoo, S Rine, J eng GM31105/GM/NIGMS NIH HHS/ P30ESO1896-12/ES/NIEHS NIH HHS/ Research Support, U.S. Gov't, P.H.S. Review 1995/01/01 Annu Rev Cell Dev Biol. 1995; 11:519-48. doi: 10.1146/annurev.cb.11.110195.002511" |
