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Lung Cancer

Title:		Exhaled breath analysis: novel approach for early detection of lung cancer
Author(s):		Chan HP; Lewis C; Thomas PS;
Address:		"Faculty of Medicine, University of New South Wales, Department of Respiratory Medicine, Prince of Wales Hospital, Randwick, NSW 2031, Australia. z3134017@student.unsw.edu.au"
Journal Title:		Lung Cancer
Year:		2009
Volume:		20080702
Issue:		2
Page Number:		164 - 168
DOI:		10.1016/j.lungcan.2008.05.020
ISSN/ISBN:		0169-5002 (Print) 0169-5002 (Linking)
Abstract:		"Lung cancer is a leading cause of cancer death, with the prognosis adversely affected by late diagnosis. Early diagnosis of lung cancer is desirable, but current evidence does not support the application of screening with techniques such as chest radiography, sputum cytology or computed tomography. Breath analysis, which includes gaseous phase analysis that measures volatile organic compounds using electronic noses, exhaled nitric oxide, and exhaled breath condensate (EBC), has been proposed as a non-invasive and simple technique to investigate neoplastic processes in the airways. EBC can be easily collected by breathing into a cooling system that condenses the water vapour in the breath. EBC has already been demonstrated to be useful in investigating inflammatory and oxidative stress changes in various respiratory conditions as it contains measurable mediators of airway inflammation and oxidative stress markers. Furthermore, EBC has also been shown to be a useful method to monitor severity of diseases such as asthma and to act as a surrogate measure of compliance to medical therapy. Presently, there still remains a relative paucity of lung cancer research involving EBC. However, since EBC is a simple, non-invasive technique that can be easily performed, even in ill patients, it has the potential to be validated for use in screening for the early diagnosis of lung cancer"
Keywords:		Biomarkers Breath Tests/*methods *Early Detection of Cancer Gas Chromatography-Mass Spectrometry Humans Luminescent Measurements Lung Neoplasms/*diagnosis;
Notes:		"MedlineChan, Hiang Ping Lewis, Craig Thomas, Paul S eng Review Ireland 2008/07/05 Lung Cancer. 2009 Feb; 63(2):164-8. doi: 10.1016/j.lungcan.2008.05.020. Epub 2008 Jul 2"