| Title: | Organ protection by volatile anesthetics in non-coronary artery bypass grafting surgery |
| Author(s): | Landoni G; Turi S; Bignami E; Zangrillo A; |
| Address: | "Department of Cardiothoracic Anesthesia and Intensive Care, Istituto Scientifico San Raffaele, Milano, Italy. landoni.giovanni@hsr.it" |
| ISSN/ISBN: | 1744-8298 (Electronic) 1479-6678 (Linking) |
| Abstract: | "The cardioprotective properties of volatile anesthetics have been widely demonstrated by numerous randomized studies and meta-analyses in the setting of cardiac surgery, above of all during coronary artery bypass grafting procedures. Recently, conflicting results have been presented in cardiac non-coronary artery bypass grafting surgery. Unfortunately, despite the existence of a great number of studies comparing a total intravenous anesthetic regimen with an inhalational regimen, at present there are no randomized studies presenting data regarding mortality and important outcomes, such as myocardial infarction, in non-cardiac surgery. In this review we analyze and present the results of the most recent and important studies regarding anesthetic preconditioning in cardiac and in noncardiac surgery. Furthermore, we focus on the emerging data from animal experiments, discussing in particular the molecular mechanisms underlying anesthetic preconditioning" |
| Keywords: | "American Heart Association *Anesthetics, Inhalation Cardiac Surgical Procedures/adverse effects/*methods Cardiotonic Agents/*therapeutic use Coronary Artery Disease/surgery Humans Ischemic Preconditioning, Myocardial Methyl Ethers Myocardium Practice Guid;" |
| Notes: | "MedlineLandoni, Giovanni Turi, Stefano Bignami, Elena Zangrillo, Alberto eng Review England 2009/11/06 Future Cardiol. 2009 Nov; 5(6):589-603. doi: 10.2217/fca.09.52" |
