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J Nat Prod

Title:		Phytotoxic and Nematicidal Components of Lavandula luisieri
Author(s):		Julio LF; Barrero AF; Herrador del Pino MM; Arteaga JF; Burillo J; Andres MF; Diaz CE; Gonzalez-Coloma A;
Address:		"Instituto de Ciencias Agrarias, Consejo Superior de Investigaciones Cientificas , Serrano 115-bis, 28006 Madrid, Spain. Departamento de Quimica Organica, Instituto de Biotecnologia, Universidad de Granada , Campus de Fuente Nueva, s/n, 18071 Granada, Spain. CIQSO, Center for Research in Sustainable Chemistry and Department of Chemical Engineering, Physical Chemistry, and Organic Chemistry, Facultad de Ciencias Experimentales, Universidad de Huelva , Campus el Carmen, 21071 Huelva, Spain. Departamento de Ciencia, Tecnologia y Universidad, Centro de Investigacion y Tecnologia Agroalimentaria de Aragon, Gobierno de Aragon , Avenida Montanana, 930, Zaragoza, Spain. Instituto de Productos Naturales y Agrobiologia, Consejo Superior de Investigaciones Cientificas , Avenida Astrofisico F. Sanchez, 3, 38206 La Laguna, Tenerife, Spain"
Journal Title:		J Nat Prod
Year:		2016
Volume:		20160122
Issue:		2
Page Number:		261 - 266
DOI:		10.1021/acs.jnatprod.5b00501
ISSN/ISBN:		1520-6025 (Electronic) 0163-3864 (Linking)
Abstract:		"Several preparations were obtained from the aerial parts of predomesticated Lavandula luisieri, including the essential oil and ethanolic, hexane, and ethyl acetate extractives. Additionally, pilot plant vapor pressure extraction was carried out at a pressure range of 0.5-1.0 bar to give a vapor pressure oil and an aqueous residue. A chemical study of the hexane extract led to the isolation of six necrodane derivatives (1, 2, and 4-7), with four of these (1, 2, 5, and 7) being new, as well as camphor, a cadinane sesquiterpene (9), tormentic acid, and ursolic acid. The EtOAc and EtOH extracts contained a mixture of phenolic compounds with rosmarinic acid being the major component. Workup of the aqueous residue resulted in the isolation of the necrodane 3 and (1R*,2S*,4R*)-p-menth-5-ene-1,2,8-triol (8), both new natural compounds. The structures of the new compounds were established based on their spectroscopic data. The phytotoxic and nematicidal activities of these compounds were evaluated"
Keywords:		"Animals Anti-Infective Agents/pharmacology Antinematodal Agents/chemistry/*isolation & purification/*pharmacology Aphids/drug effects Lavandula/chemistry Molecular Structure Monoterpenes Nuclear Magnetic Resonance, Biomolecular Oils, Volatile/analysis Pla;"
Notes:		"MedlineJulio, Luis F Barrero, Alejandro F Herrador del Pino, M Mar Arteaga, Jesus F Burillo, Jesus Andres, Maria Fe Diaz, Carmen E Gonzalez-Coloma, Azucena eng Research Support, Non-U.S. Gov't 2016/01/23 J Nat Prod. 2016 Feb 26; 79(2):261-6. doi: 10.1021/acs.jnatprod.5b00501. Epub 2016 Jan 22"