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Lab Chip

Title:		Rapid microfabrication of solvent-resistant biocompatible microfluidic devices
Author(s):		Hung LH; Lin R; Lee AP;
Address:		"Department of Biomedical Engineering, University of California at Irvine, 3120 Natural Sciences II, Irvine, CA 92697, USA. lhung@uci.edu"
Journal Title:		Lab Chip
Year:		2008
Volume:		20080408
Issue:		6
Page Number:		983 - 987
DOI:		10.1039/b717710k
ISSN/ISBN:		1473-0197 (Print) 1473-0189 (Linking)
Abstract:		"This paper presents a rapid, simple, and low-cost fabrication method to prepare solvent resistant and biocompatible microfluidic devices with three-dimensional geometries. The devices were fabricated in thiolene and replicated from PDMS master with high molding fidelity. Good chemical compatibility for organic solvents allows volatile chemicals in synthesis and analysis applications. The surface can be processed to be hydrophobic or hydrophilic for water-in-oil and oil-in-water emulsions. Monodisperse organic solvent droplet generation is demonstrated to be reproducible in thiolene microchannels without swelling. The thiolene surface prevents cell adhesion but normal cell growth and adhesion on glass substrates is not affected by the adjacent thiolene patterns"
Keywords:		Biocompatible Materials/*chemistry Cell Adhesion Cell Culture Techniques/instrumentation/*methods Cell Proliferation Dimethylpolysiloxanes/chemistry Equipment Design Glass/chemistry HeLa Cells Humans Hydrophobic and Hydrophilic Interactions Microfluidic A;
Notes:		"MedlineHung, Lung-Hsin Lin, Robert Lee, Abraham Phillip eng England 2008/05/24 Lab Chip. 2008 Jun; 8(6):983-7. doi: 10.1039/b717710k. Epub 2008 Apr 8"