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J Thorac Cardiovasc Surg

Title:		Perioperative exposure to volatile organic compounds in neonates undergoing cardiac surgery
Author(s):		Gaynor JW; Graham EM; Bhandari D; Fenchel M; Bradman A; Klepczynski B; Collier H; Ittenbach RF; Reese CM; Blount BC;
Address:		"Division of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa. Electronic address: gaynor@chop.edu. Department of Pediatrics, Division of Cardiology, Medical University of South Carolina, Charleston, SC. Division of Laboratory Sciences, National Center for Environmental Health, Atlanta, Ga. Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Department of Public Health, University of California, Merced, Merced, Calif. Division of Cardiothoracic Surgery, Department of Surgery, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa. Pharmacy Residency Program, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa"
Journal Title:		J Thorac Cardiovasc Surg
Year:		2023
Volume:		20230807
Issue:
Page Number:		-
DOI:		10.1016/j.jtcvs.2023.07.049
ISSN/ISBN:		1097-685X (Electronic) 0022-5223 (Linking)
Abstract:		"OBJECTIVE: Volatile organic compounds (VOCs) are used in the sterilization and manufacture of medical equipment. These compounds have high vapor pressures with low water solubility and are emitted as gases from solids or liquids. They can be mutagenic, neurotoxic, genotoxic, and/or carcinogenic. Safe limits of exposure are not known for neonates. This study examined determinants of exposure in newborns undergoing cardiac surgery. METHODS: Twenty metabolites of 16 VOCs (eg, xylene, cyanide, acrolein, acrylonitrile, N, N-dimethylformamide, 1,3-butadiene, styrene, and benzene) were measured as metabolites in daily urine samples collected from 10 neonates undergoing cardiac operations (n = 150 samples). Metabolites were quantified using reversed-phase ultra-high performance liquid chromatography and electrospray ionization tandem mass spectrometry. Repeated measures analysis of covariance was performed for each metabolite to examine associations with use of medical devices. RESULTS: At least 3 metabolites were detected in every sample. The median number of metabolites detected in each sample was 14 (range, 3-15). In a model controlling for other factors, the use of extracorporeal membrane oxygenation was associated with significantly (P
Keywords:		congenital heart disease extracorporeal membrane oxygenation intensive care unit volatile organic compounds;
Notes:		"PublisherGaynor, J William Graham, Eric M Bhandari, Deepak Fenchel, Matthew Bradman, Asa Klepczynski, Brenna Collier, Hailey Ittenbach, Richard F Reese, Christopher M Blount, Benjamin C eng 2023/08/10 J Thorac Cardiovasc Surg. 2023 Aug 7:S0022-5223(23)00658-X. doi: 10.1016/j.jtcvs.2023.07.049"