| Title: | Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis |
| Author(s): | Gaffin JM; Kanchongkittiphon W; Phipatanakul W; |
| Address: | "Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA; USA; Harvard Medical School, Boston, MA, USA. Electronic address: jonathan.gaffin@childrens.harvard.edu. Division of Immunology, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: champw@hotmail.com. Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Boston, MA, USA. Electronic address: wanda.phipatanakul@childrens.harvard.edu" |
| DOI: | 10.1016/j.intimp.2014.06.005 |
| ISSN/ISBN: | 1878-1705 (Electronic) 1567-5769 (Print) 1567-5769 (Linking) |
| Abstract: | "BACKGROUND: The prevalence of asthma has increased dramatically over the past several decades. While hereditary factors are highly important, the rapid rise outstrips the pace of genomic variation. Great emphasis has been placed on potential modifiable early life exposures leading to childhood asthma. METHODS: We reviewed the recent medical literature for important studies discussing the role of the perinatal and early childhood exposures and the inception of childhood asthma. RESULTS AND DISCUSSION: Early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO(2)), ozone (O(3)), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms" |
| Keywords: | "*Air Pollution/adverse effects *Allergens/adverse effects/immunology Asthma/*epidemiology/etiology/*immunology Child Child, Preschool *Environmental Exposure/adverse effects Female Humans Infant Infant, Newborn Perinatal Care Pregnancy Risk Virus Diseases;" |
| Notes: | "MedlineGaffin, Jonathan M Kanchongkittiphon, Watcharoot Phipatanakul, Wanda eng U10HL098102/HL/NHLBI NIH HHS/ R01 AI073964/AI/NIAID NIH HHS/ K23 AI106945/AI/NIAID NIH HHS/ R01 AI 073964-02S1/AI/NIAID NIH HHS/ U10 HL098102/HL/NHLBI NIH HHS/ R01 AI 073964/AI/NIAID NIH HHS/ UL1 TR001102/TR/NCATS NIH HHS/ UL1 RR025758/RR/NCRR NIH HHS/ K24 AI 106822/AI/NIAID NIH HHS/ K24 AI106822/AI/NIAID NIH HHS/ UL1 RR 025758/RR/NCRR NIH HHS/ K23AI106945-01/AI/NIAID NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review Netherlands 2014/06/22 Int Immunopharmacol. 2014 Sep; 22(1):21-30. doi: 10.1016/j.intimp.2014.06.005. Epub 2014 Jun 19" |
