| Title: | Plasticity of pheromone-mediated avoidance behavior in C. elegans |
| Address: | "Department of Brain and Cognitive Sciences, DGIST, Daegu, Republic of Korea. Korea Brain Research Institute (KBRI), Daegu, Republic of Korea" |
| DOI: | 10.1080/01677063.2020.1802723 |
| ISSN/ISBN: | 1563-5260 (Electronic) 0167-7063 (Linking) |
| Abstract: | "Caenorhabditis elegans secretes a complex cocktail of small chemicals collectively called ascaroside pheromones which serves as a chemical language for intra-species communication. Subsets of ascarosides have been shown to mediate a broad spectrum of C. elegans behavior and development, such as gender-specific attraction, repulsion, aggregation, olfactory plasticity, and dauer formation. Recent studies show that specific components of ascarosides elicit a rapid avoidance response that allows animals to avoid predators and escape from unfavorable conditions. Moreover, this avoidance behavior is modulated by external conditions, internal states, and previous experience, indicating that pheromone avoidance behavior is highly plastic. In this review, we describe molecular and circuit mechanisms underlying plasticity in pheromone avoidance behavior which pave a way to better understanding circuit mechanisms underlying behavioral plasticity in higher animals, including humans" |
| Keywords: | "Adaptation, Physiological/*physiology Animals Avoidance Learning/*physiology Caenorhabditis elegans/*physiology Connectome Feeding Behavior/physiology Forecasting Glycolipids/chemistry/physiology Lipids/chemistry/physiology Nematoda/physiology Neural Path;" |
| Notes: | "MedlineCheon, YongJin Hwang, Hyeonjeong Kim, Kyuhyung eng Comparative Study Research Support, Non-U.S. Gov't England 2020/08/20 J Neurogenet. 2020 Sep-Dec; 34(3-4):420-426. doi: 10.1080/01677063.2020.1802723. Epub 2020 Aug 19" |
