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Phys Chem Chem Phys

Title:		Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity
Author(s):		Borsacchi S; Geppi M; Macchi S; Ninham BW; Fratini E; Ambrosi M; Baglioni P; Lo Nostro P;
Address:		"Istituto di Chimica dei Composti OrganoMetallici (ICCOM) del CNR, 56124 Pisa, Italy. Department of Chemistry and Industrial Chemistry, University of Pisa, 56124 Pisa, Italy. Department of Chemistry & CSGI, University of Florence, 50019 Sesto Fiorentino (Firenze), Italy. PLN@csgi.unifi.it and Department of Applied Mathematics, Research School of Physical Sciences and Engineering, Australian National University, Canberra, ACT 0200, Australia. Department of Chemistry & CSGI, University of Florence, 50019 Sesto Fiorentino (Firenze), Italy. PLN@csgi.unifi.it. Department of Chemistry & CSGI, University of Florence, 50019 Sesto Fiorentino (Firenze), Italy. PLN@csgi.unifi.it and Enzo Ferroni Foundation, 50019 Sesto Fiorentino (Firenze), Italy"
Journal Title:		Phys Chem Chem Phys
Year:		2016
Volume:		18
Issue:		22
Page Number:		15375 - 15383
DOI:		10.1039/c6cp00659k
ISSN/ISBN:		1463-9084 (Electronic) 1463-9076 (Linking)
Abstract:		"The phase behavior of a mixture of a typical insect pheromone (olean) and a phospholipid (DOPC)/water dispersion is extensively explored through SAXS, NMR and DSC experiments. The results mimic those obtained with anaesthetics in phospholipid/water systems. They also mimic the behavior and microstructure of ternary mixtures of a membrane mimetic, bilayer-forming double chained surfactants, oils and water. Taken together with recent models for conduction of the nervous impulse, all hint at lipid involvement and the underlying unity in mechanisms of pheromone, anaesthetic and hydrophobic drugs, where a local phase change in the lipid membrane architecture may be at least partly involved in the transmission of the signal"
Keywords:
Notes:		"PubMed-not-MEDLINEBorsacchi, Silvia Geppi, Marco Macchi, Sara Ninham, Barry W Fratini, Emiliano Ambrosi, Moira Baglioni, Piero Lo Nostro, Pierandrea eng England 2016/05/24 Phys Chem Chem Phys. 2016 Jun 1; 18(22):15375-83. doi: 10.1039/c6cp00659k"