« Previous AbstractApplication of supercritical fluid extraction (SFE) to predict bioremediation efficacy of long-term composting of PAH-contaminated soil    Next AbstractAn Impedimetric Biosensor for Detection of Volatile Organic Compounds in Food »

Environ Int

Title:		"Associations between blood volatile organic compounds, and changes in hematologic and biochemical profiles, in a population-based study"
Author(s):		Cakmak S; Cole C; Hebbern C; Andrade J; Dales R;
Address:		"Population Studies Division, Environmental Health Science & Research Bureau, Health Canada, 101 Tunney's Pasture Driveway, Ottawa, ON K1A 0K9, Canada. Electronic address: sabit.cakmak@canada.ca. Indoor Air Contaminants Assessment Section, Healthy Environments and Consumer Safety Branch, Health Canada, 269 Laurier Avenue, Ottawa, ON K1A 0K9, Canada. Climate Change and Innovation Bureau, Health Canada, 269 Laurier Avenue, Ottawa, ON K1A 0K9, Canada. Population Studies Division, Environmental Health Science & Research Bureau, Health Canada, 101 Tunney's Pasture Driveway, Ottawa, ON K1A 0K9, Canada. Population Studies Division, Environmental Health Science & Research Bureau, Health Canada and Ottawa Hospital Research Institute. 101 Tunney's Pasture Driveway, Ottawa, ON K1A 0K9, Canada; University of Ottawa and Ottawa Hospital Research Institute, Canada"
Journal Title:		Environ Int
Year:		2020
Volume:		20200915
Issue:
Page Number:		106121 -
DOI:		10.1016/j.envint.2020.106121
ISSN/ISBN:		1873-6750 (Electronic) 0160-4120 (Linking)
Abstract:		"OBJECTIVE: To investigate the influence of volatile organic compound (VOC) levels in blood, on hematological and serum biochemical parameters in the Canadian population. METHODS: We tested the association between seven selected VOCs and hematological profiles and serum tests reflecting liver and kidney function and glucose metabolism using a cross-sectional study design in 3950 participants of the Canadian Health Measures Survey from 2012 to 2015. We used generalized linear mixed models adjusting for age, sex, smoking, alcohol consumption, BMI, education and household income. RESULTS: An increase in blood concentration equivalent to the geometric mean for benzene, ethylbenzene, toluene, m-, p-xylenes, styrene, and total xylenes was associated with 0.68% (95% CI 0.36, 1.0) to 0.91% (95% CI 0.52, 1.3) increase in hemoglobin, and a 1.79% (95% CI 0.96, 2.62) to 4.11% (95% CI 3.11, 5.11) increase in total white blood cell count. Ethylbenzene, toluene, m-, p-xylenes and styrene were positively associated with increased platelet counts. A geometric mean increase for all VOCs was associated with decreases in creatinine. m- and p-xylenes were associated with a significant change in every measured blood cell count and liver function parameter, and in creatinine. Ethylbenzene was also positively associated with an increase in every measured hematologic parameter, two of the three liver function tests, and creatinine. Results were similar when stratified by age, but differed by smoking status and sex. CONCLUSIONS: This study provides evidence that VOCs in blood, at levels found in the Canadian population, may influence blood cell counts and indicators of liver and kidney function, including an inverse association between serum VOC and creatinine. This novel finding merits further investigation to understand the impact of VOCs on human physiology and population health"
Keywords:		*Air Pollutants/analysis/toxicity Benzene/analysis Canada Cross-Sectional Studies Environmental Monitoring Humans Toluene/analysis *Volatile Organic Compounds/analysis Biochemical profiles Blood cell counts Hematologic profiles Kidney function Liver funct;
Notes:		"MedlineCakmak, Sabit Cole, Christie Hebbern, Chris Andrade, Julie Dales, Robert eng Netherlands 2020/09/19 Environ Int. 2020 Dec; 145:106121. doi: 10.1016/j.envint.2020.106121. Epub 2020 Sep 15"