| Title: | VOC pattern recognition of lung cancer: a comparative evaluation of different dog- and eNose-based strategies using different sampling materials |
| Author(s): | Biehl W; Hattesohl A; Jorres RA; Duell T; Althohn U; Koczulla AR; Schmetzer H; |
| Address: | "Medical Department III, University Hospital Grosshadern, Ludwig-Maximilians-University , Munich , Germany. Department of Pulmonary Rehabilitation, Philipps-University of Marburg, German Center for Lung Research (DZL) , Marburg , Germany. Department of Respiratory Medicine and Pulmonary Rehabilitation, Schoen Klinik Berchtesgadener Land , Schoenau am Koenigssee , Germany. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital , Munich , LMU , Germany. Department for Oncology, Asklepios Lungenfachkliniken Muenich-Gauting , Germany. Evidensia Tierarztliche Klinik fur Kleintiere Norderstedt GmbH , Norderstedt , Germany" |
| DOI: | 10.1080/0284186X.2019.1634284 |
| ISSN/ISBN: | 1651-226X (Electronic) 0284-186X (Linking) |
| Abstract: | "Background: It has been reported that canine scent tests offer the possibility to screen for cancer. Assuming that breath samples can be collected with carrier materials, we tested the practicability of different carrier materials to be presented to dogs and validated and compared results with an electronic nose (eNose). Moreover, we hypothesized that cancer detection ability of dogs differs according to their working experience. Methods: In a methodological approach, two dog teams participated, one using experienced working dogs and the other ordinary household dogs to find the most qualified dogs and training method. To find best carrier material for breath sampling we compared charcoal containing glass tubes and fleece masks. In a second validating part, experienced working dogs were trained with improved training strategies. For breath sampling, two different, previously successfully tested fleece-based carrier materials were used: one was used with the dog team and both materials were compared with eNose. Results: In the methodological approach, it turned out that the charcoal-based sampling strategy qualified not sufficiently for VOC-detection. Moreover, we could determine that using experienced working dogs provided several advantages. Overall results of dogs in the validating part regarding specificity were 83%, regarding sensitivity 56%, but with great variability among dogs. Using eNose for breath analysis collected with both fleece carrier materials, specificity was 97% and sensitivity 89-100%. Conclusion: Our data confirmed that the diagnostic accuracy of dogs depended on the type of dog training and on the carrier materials. A comparison of breath samples analysis with an eNose achieved better results for both, sensitivity and specificity than for dogs. The use of fleece masks or fleeces in glass tubes as a sampling material can be recommended as successful VOC carriers, encouraging their use for clinical screenings" |
| Keywords: | "Adult Aged Aged, 80 and over Animals Breath Tests/instrumentation/*methods Conditioning, Psychological *Dogs *Electronic Nose Exhalation Female Glass Humans Lung Neoplasms/*diagnosis Male Masks Middle Aged Pets Reproducibility of Results Sensitivity and S;" |
| Notes: | "MedlineBiehl, Wiebke Hattesohl, Akira Jorres, Rudolf A Duell, Thomas Althohn, Ulrike Koczulla, Andreas Rembert Schmetzer, Helga eng Comparative Study England 2019/07/18 Acta Oncol. 2019 Sep; 58(9):1216-1224. doi: 10.1080/0284186X.2019.1634284. Epub 2019 Jul 16" |
