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J Gerontol A Biol Sci Med Sci

Title:		Protein-repair and hormone-signaling pathways specify dauer and adult longevity and dauer development in Caenorhabditis elegans
Author(s):		Banfield KL; Gomez TA; Lee W; Clarke S; Larsen PL;
Address:		"Department of Cellular and Structural Biology, University of Texas Science Center at San Antonio, San Antonio, TX 78229, USA"
Journal Title:		J Gerontol A Biol Sci Med Sci
Year:		2008
Volume:		63
Issue:		8
Page Number:		798 - 808
DOI:		10.1093/gerona/63.8.798
ISSN/ISBN:		1079-5006 (Print) 1079-5006 (Linking)
Abstract:		"Protein damage that accumulates during aging can be mitigated by a repair methyltransferase, the l-isoaspartyl-O-methyltransferase. In Caenorhabditis elegans, the pcm-1 gene encodes this enzyme. In response to pheromone, we show that pcm-1 mutants form fewer dauer larvae with reduced survival due to loss of the methyltransferase activity. Mutations in daf-2, an insulin/insulin-like growth factor-1-like receptor, and daf-7, a transforming growth factor-beta-like ligand, modulate pcm-1 dauer defects. Additionally, daf-2 and daf-7 mutant dauer larvae live significantly longer than wild type. Although dauer larvae are resistant to many environmental stressors, a proportionately larger decrease in dauer larvae life spans occurred at 25 degrees C compared to 20 degrees C than in adult life span. At 25 degrees C, mutation of the daf-7 or pcm-1 genes does not change adult life span, whereas mutation of the daf-2 gene and overexpression of PCM-1 increases adult life span. Thus, there are both overlapping and distinct mechanisms that specify dauer and adult longevity"
Keywords:		"Aging/genetics/*metabolism Animals Caenorhabditis elegans/genetics/*physiology Caenorhabditis elegans Proteins/genetics/*physiology Cell Cycle Proteins/genetics/*physiology Epistasis, Genetic Forkhead Transcription Factors Gene Expression Regulation, Deve;"
Notes:		"MedlineBanfield, Kelley L Gomez, Tara A Lee, Wendy Clarke, Steven Larsen, Pamela L eng R37 GM026020-27S1/GM/NIGMS NIH HHS/ T32 GM007185-30/GM/NIGMS NIH HHS/ R01 GM026020/GM/NIGMS NIH HHS/ T32 GM007185/GM/NIGMS NIH HHS/ T32 GM007185-29/GM/NIGMS NIH HHS/ R37 GM026020-27/GM/NIGMS NIH HHS/ GM 26020/GM/NIGMS NIH HHS/ T32 GM007185-31/GM/NIGMS NIH HHS/ R37 GM026020-30/GM/NIGMS NIH HHS/ R37 GM026020/GM/NIGMS NIH HHS/ R37 GM026020-29/GM/NIGMS NIH HHS/ R01 AG018000-04/AG/NIA NIH HHS/ R37 GM026020-26/GM/NIGMS NIH HHS/ R37 GM026020-28/GM/NIGMS NIH HHS/ R01 AG018000/AG/NIA NIH HHS/ AG 18000/AG/NIA NIH HHS/ T32 GM 07185/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2008/09/06 J Gerontol A Biol Sci Med Sci. 2008 Aug; 63(8):798-808. doi: 10.1093/gerona/63.8.798"