| Title: | The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in Caenorhabditis elegans |
| Author(s): | Aprison EZ; Dzitoyeva S; Ruvinsky I; |
| Address: | "Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA" |
| ISSN/ISBN: | 1471-2954 (Electronic) 0962-8452 (Print) 0962-8452 (Linking) |
| Abstract: | "Behaviour and physiology are altered in reproducing animals, but neuronal circuits that regulate these changes remain largely unknown. Insights into mechanisms that regulate and possibly coordinate reproduction-related traits could be gleaned from the study of sex pheromones that can improve the reproductive success of potential mating partners. In Caenorhabditis elegans, the prominent male pheromone, ascr#10, modifies reproductive behaviour and several aspects of reproductive physiology in hermaphrodite recipients, including improving oocyte quality. Here we show that a circuit that contains serotonin-producing and serotonin-uptaking neurons plays a key role in mediating effects of ascr#10 on germline development and egg laying behaviour. We also demonstrate that increased serotonin signalling promotes proliferation of germline progenitors in adult hermaphrodites. Our results establish a role for serotonin in maintaining germline quality and highlight a simple neuronal circuit that acts as a linchpin that couples food intake, mating behaviour, reproductive output, and germline renewal and provisioning" |
| Keywords: | Male Animals *Caenorhabditis elegans *Serotonin Germ Cells Oviposition Transcription Factors Cell Proliferation C.elegans coordination germline pheromone reproduction serotonin; |
| Notes: | "MedlineAprison, Erin Z Dzitoyeva, Svetlana Ruvinsky, Ilya eng R01 GM126125/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ Research Support, N.I.H., Extramural England 2022/12/01 Proc Biol Sci. 2022 Nov 30; 289(1987):20220913. doi: 10.1098/rspb.2022.0913. Epub 2022 Nov 30" |
