| Title: | An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations |
| Author(s): | Butcher RA; Ragains JR; Clardy J; |
| Address: | "Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA" |
| ISSN/ISBN: | 1523-7052 (Electronic) 1523-7060 (Print) 1523-7052 (Linking) |
| Abstract: | "In Caenorhabditis elegans, the dauer pheromone, which consists of a number of derivatives of the 3,6-dideoxysugar ascarylose, is the primary cue for entry into the stress-resistant, 'nonaging' dauer larval stage. Here, using activity-guided fractionation and NMR-based structure elucidation, a structurally novel, indole-3-carboxyl-modified ascaroside is identified that promotes dauer formation at low nanomolar concentrations but inhibits dauer formation at higher concentrations" |
| Keywords: | Animals Caenorhabditis elegans/*chemistry/growth & development/physiology Hexoses/*chemistry/*metabolism/pharmacology Indoles/*chemistry/metabolism/pharmacology Larva/growth & development Molecular Structure Pheromones/*chemistry/*metabolism/pharmacology; |
| Notes: | "MedlineButcher, Rebecca A Ragains, Justin R Clardy, Jon eng GM077943/GM/NIGMS NIH HHS/ F32 GM077943/GM/NIGMS NIH HHS/ R01 CA024487-30/CA/NCI NIH HHS/ R01 CA024487/CA/NCI NIH HHS/ R01 CA024487-29/CA/NCI NIH HHS/ R00 GM087533/GM/NIGMS NIH HHS/ CA24487/CA/NCI NIH HHS/ K99 GM087533/GM/NIGMS NIH HHS/ Research Support, N.I.H., Extramural 2009/06/24 Org Lett. 2009 Jul 16; 11(14):3100-3. doi: 10.1021/ol901011c" |
