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Biomed Chromatogr

Title:		Human exhaled air analytics: biomarkers of diseases
Author(s):		Buszewski B; Kesy M; Ligor T; Amann A;
Address:		"Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87-100 Torun, Poland. bbusz@chem.uni.torun.pl"
Journal Title:		Biomed Chromatogr
Year:		2007
Volume:		21
Issue:		6
Page Number:		553 - 566
DOI:		10.1002/bmc.835
ISSN/ISBN:		0269-3879 (Print) 0269-3879 (Linking)
Abstract:		"Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed"
Keywords:		"Adsorption Air/analysis Biomarkers/analysis Breath Tests/*methods Diabetes Mellitus/diagnosis Gas Chromatography-Mass Spectrometry Humans Kidney Diseases/diagnosis Liver Diseases/diagnosis Lung Diseases/diagnosis Monitoring, Physiologic/methods Organic Ch;"
Notes:		"MedlineBuszewski, Boguslaw Kesy, Martyna Ligor, Tomasz Amann, Anton eng Research Support, Non-U.S. Gov't Review England 2007/04/14 Biomed Chromatogr. 2007 Jun; 21(6):553-66. doi: 10.1002/bmc.835"