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J Pineal Res

Title:		"Homeostatic crosstalk among gut microbiome, hypothalamic and hepatic circadian clock oscillations, immunity and metabolism in response to different light-dark cycles: A multiomics study"
Author(s):		Zhen Y; Wang Y; He F; Chen Y; Hu L; Ge L; Wang Y; Wei W; Rahmat A; Loor JJ; Wang M;
Address:		"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, China. State Key Laboratory of Sheep Genetic Improvement and Healthy Production, Xinjiang Academy of Agricultural Reclamation Sciences, Shihezi, Xinjiang, China. Human and Animal Physiology, Wageningen University & Research, Wageningen, The Netherlands. Mammalian Nutrition Physiology Genomics, Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, Illinois, USA"
Journal Title:		J Pineal Res
Year:		2023
Volume:		20230718
Issue:		2
Page Number:		e12892 -
DOI:		10.1111/jpi.12892
ISSN/ISBN:		1600-079X (Electronic) 0742-3098 (Linking)
Abstract:		"The accelerated pace of life at present time has resulted in tremendous alterations in living patterns. Changes in diet and eating patterns, in particular, coupled with irregular light-dark (LD) cycles will further induce circadian misalignment and lead to disease. Emerging data has highlighted the regulatory effects of diet and eating patterns on the host-microbe interactions with the circadian clock (CC), immunity, and metabolism. Herein, we studied how LD cycles regulate the homeostatic crosstalk among the gut microbiome (GM), hypothalamic and hepatic CC oscillations, and immunity and metabolism using multiomics approaches. Our data demonstrated that central CC oscillations lost rhythmicity under irregular LD cycles, but LD cycles had minimal effects on diurnal expression of peripheral CC genes in the liver including Bmal1. We further demonstrated that the GM could regulate hepatic circadian rhythms under irregular LD cycles, the candidate bacteria including Limosilactobacillus, Actinomyces, Veillonella, Prevotella, Campylobacter, Faecalibacterium, Kingella, and Clostridia vadinBB60 et al. A comparative transcriptomic study of innate immune genes indicated that different LD cycles had varying effects on immune functions, while irregular LD cycles had greater impacts on hepatic innate immune functions than those in the hypothalamus. Extreme LD cycle alterations (LD0/24 and LD24/0) had worse impacts than slight alterations (LD8/16 and LD16/8), and led to gut dysbiosis in mice receiving antibiotics. Metabolome data also demonstrated that hepatic tryptophan metabolism mediated the homeostatic crosstalk among GM-liver-brain axis in response to different LD cycles. These research findings highlighted that GM could regulate immune and metabolic disorders induced by circadian dysregulation. Further, the data provided potential targets for developing probiotics for individuals with circadian disruption such as shift workers"
Keywords:		Animals Mice Photoperiod *Circadian Clocks/physiology *Gastrointestinal Microbiome Multiomics *Melatonin/metabolism Circadian Rhythm/physiology Liver/metabolism Hypothalamus/metabolism circadian clock gut microbiome host-microbes interaction innate immune;
Notes:		"MedlineZhen, Yongkang Wang, Yifan He, Feiyang Chen, Yifei Hu, Liangyu Ge, Ling Wang, Yusu Wei, Wenjun Rahmat, Ali Loor, Juan J Wang, Mengzhi eng 31672446/The Natural Science Foundation of China/ NCG202232/The State Key Laboratory of Sheep Genetic Improvement and Healthy Production/ 2021ZD07/The State Key Laboratory of Sheep Genetic Improvement and Healthy Production/ 2004DA125184F1715/The National Key Laboratory of Animal Nutrition/ PAPD/The Priority Academic Program Development of Jiangsu Higher Education Institutions, China/ England 2023/06/15 J Pineal Res. 2023 Sep; 75(2):e12892. doi: 10.1111/jpi.12892. Epub 2023 Jul 18"