| Title: | Incidence of retinal vein occlusion with long-term exposure to ambient air pollution |
| Author(s): | Zhang HW; Lin CW; Kok VC; Tseng CH; Lin YP; Li TC; Sung FC; Wen CP; Hsiung CA; Hsu CY; |
| Address: | "PhD Program for Aging, China Medical University, Taichung, Taiwan. Institute of Electrical Control Engineering, Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. Disease Informatics Research Group, Asia University Taiwan, Taichung, Taiwan. Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan. Department of Neurology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan. Graduate Institute of Biostatistics, College of Public Health, China Medical University, Taichung, Taiwan. Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan. Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan" |
| DOI: | 10.1371/journal.pone.0222895 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "This study aimed to investigate whether long-term exposure to airborne hydrocarbons, including volatile organic compounds, increases the risk of developing retinal vein occlusion (RVO) among the population of Taiwan. A retrospective cohort study involving 855,297 people was conducted. Cox proportional hazards regression analysis fitted the multiple pollutant models for two targeted pollutants, including total hydrocarbons (THC), nonmethane hydrocarbons (NMHC) were used, and the risk of RVO was estimated. The chi-squared test and one-way analysis of variance were used to test differences in demographics and comorbidity distribution among tertiles of the targeted pollutants. Before controlling for multiple pollutants, hazard ratios for the overall population were 19.88 (95% CI: 17.56-22.50) at 0.51-ppm increases in THC and 4.33 (95% CI: 3.97-4.73) at 0.27-ppm increases in NMHC. The highest adjusted hazard ratios for different multiple pollutant models of each targeted pollutant were statistically significant (all p values were |
| Keywords: | "Adolescent Adult Air Pollutants/*adverse effects Air Pollution/*adverse effects/statistics & numerical data Child Databases, Factual/statistics & numerical data Female Humans Hydrocarbons/adverse effects Incidence Male Middle Aged Proportional Hazards Mod;" |
| Notes: | "MedlineZhang, Han-Wei Lin, Chao-Wen Kok, Victor C Tseng, Chun-Hung Lin, Yuan-Pei Li, Tsai-Chung Sung, Fung-Chang Wen, Chi Pang Hsiung, Chao A Hsu, Chung Y eng 2019/09/25 PLoS One. 2019 Sep 24; 14(9):e0222895. doi: 10.1371/journal.pone.0222895. eCollection 2019" |
