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Mediators Inflamm

Title:		Dietary Supplementation of L-Arginine and N-Carbamylglutamate Attenuated the Hepatic Inflammatory Response and Apoptosis in Suckling Lambs with Intrauterine Growth Retardation
Author(s):		Zhang H; Fan Y; Elsabagh M; Guo S; Wang M; Jiang H;
Address:		"Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition, College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China. Joint International Research Laboratory of Agriculture and Agri-Product Safety, The Ministry of Education of China, Yangzhou University, Yangzhou 225009, China. Department of Animal Production and Technology, Faculty of Agricultural Sciences and Technologies, Nigde Omer Halisdemir University, Nigde 51240, Turkey. Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh 33516, Egypt. Department of Pediatrics, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou 225001, China"
Journal Title:		Mediators Inflamm
Year:		2020
Volume:		20200404
Issue:
Page Number:		2453537 -
DOI:		10.1155/2020/2453537
ISSN/ISBN:		1466-1861 (Electronic) 0962-9351 (Print) 0962-9351 (Linking)
Abstract:		"L-arginine (Arg) is a semiessential amino acid with several physiological functions. N-Carbamylglutamate (NCG) can promote the synthesis of endogenous Arg in mammals. However, the roles of Arg or NCG on hepatic inflammation and apoptosis in suckling lambs suffering from intrauterine growth restriction (IUGR) are still unclear. The current work is aimed at examining the effects of dietary Arg and NCG on inflammatory and hepatocyte apoptosis in IUGR suckling lambs. On day 7 after birth, 48 newborn Hu lambs were selected from a cohort of 432 twin lambs. Normal-birthweight and IUGR Hu lambs were allocated randomly (n = 12/group) to control (CON), IUGR, IUGR+1% Arg, or IUGR+0.1% NCG groups. Lambs were fed for 21 days from 7 to 28 days old. Compared with CON lambs, relative protein 53 (P53), apoptosis antigen 1 (Fas), Bcl-2-associated X protein (Bax), caspase-3, cytochrome C, tumor necrosis factor alpha (TNF-alpha), nuclear factor kappa-B (NF-kappaB) p65, and NF-kappaB pp65 protein levels were higher (P < 0.05) in liver from IUGR lambs, whereas those in liver from IUGR lambs under Arg or NCG treatment were lower than those in IUGR lambs. These findings indicated that supplementing Arg or NCG reduced the contents of proinflammatory cytokines at the same time when the apoptosis-related pathway was being suppressed, thus suppressing the IUGR-induced apoptosis of hepatic cells"
Keywords:		"Animals Apoptosis/drug effects Arginine/*therapeutic use Blotting, Western Body Weight/drug effects Caspase 3/metabolism Caspase 8/metabolism Caspase 9/metabolism Cytochromes c/metabolism Female Fetal Growth Retardation/*drug therapy/*metabolism Glutamate;"
Notes:		"MedlineZhang, Hao Fan, Yaotian Elsabagh, Mabrouk Guo, Shuang Wang, Mengzhi Jiang, Honghua eng 2020/04/24 Mediators Inflamm. 2020 Apr 4; 2020:2453537. doi: 10.1155/2020/2453537. eCollection 2020"