| Title: | A gate-opening controlled metal-organic framework for selective solid-phase microextraction of aldehydes from exhaled breath of lung cancer patients |
| Author(s): | Yu LQ; Wang LY; Su FH; Hao PY; Wang H; Lv YK; |
| Address: | "College of Chemistry and Environmental Science, Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding, 071002, China. yuliqinghbdx@126.com. College of Chemistry and Environmental Science, Key Laboratory of Analytical Science and Technology of Hebei Province, Hebei University, Baoding, 071002, China" |
| DOI: | 10.1007/s00604-018-2843-1 |
| ISSN/ISBN: | 1436-5073 (Electronic) 0026-3672 (Linking) |
| Abstract: | "A stainless steel fiber was coated with a gate-opening controlled metal-organic framework ZIF-7 via a sol-gel method and applied to the solid-phase microextraction of aldehydes (hexanal, heptanal, octanal, nonanal, decanal) from exhaled breath by lung cancer patients. The effects of temperature and time on the sorption and desorption were optimized. Under optimum condition, the modified fiber displays enrichment factors (typically ranging from 300 to 10,000), low limits of detection (0.61-0.84 mug L(-1)), and wide linear ranges of hexanal, heptanal (5-500 mug L(-1)) and octanal, nonanal, decanal (10-1000 mug L(-1)). The high extraction capability for aldehydes is thought to result from (a) the combined effects of the large surface area and the unique porous structure of the ZIF-7, (b) the hydrophobicity and gate-opening effect of the sorbent, (c) the high selectivity of the window, and (d) the presence of unsaturated metal-coordination sites. The coated fiber is thermally stable and can be re-used >150 times. The relative standard deviation (RSD) for six replicate extractions using a single fiber ranged from 1.4-15.3% for intra-day and 2.4-16.1% for inter-day. The fiber-to-fiber reproducibility for three fibers prepared in parallel was in the range of 2.4-12.6% (RSD). The method was applied to the extraction of aldehydes from real samples and to the quantitation by gas chromatography. Recoveries from spiked samples ranged from 84 to 113%. Graphical abstract A metal-organic framework ZIF-7 coated stainless steel fiber was prepared via sol-gel method. The self-made fiber was applied in the solid phase microextraction of aldehydes from exhaled breath of lung cancer patients" |
| Keywords: | Aldehydes/*analysis/*isolation & purification *Breath Tests *Exhalation Humans Limit of Detection *Lung Neoplasms Metal-Organic Frameworks/*chemistry Solid Phase Microextraction/*methods Temperature Time Factors Benzimidazole Breath analysis Flame ionic d; |
| Notes: | "MedlineYu, Li-Qing Wang, Li-Ya Su, Fei-Hong Hao, Ping-Yu Wang, Huan Lv, Yun-Kai eng 21375032/The National Natural Science Foundation of China/International 21505031/The National Natural Science Foundation of China/International B2016201210/The Natural Science Foundation of Hebei Province/International B2016201213/The Natural Science Foundation of Hebei Province/International Research Support, Non-U.S. Gov't Austria 2018/05/24 Mikrochim Acta. 2018 May 22; 185(6):307. doi: 10.1007/s00604-018-2843-1" |
