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J Transl Int Med

Title:		Gas chromatography-mass spectrometry pilot study to identify volatile organic compound biomarkers of childhood obesity with dyslipidemia in exhaled breath
Author(s):		Xu T; Wang J; Tan J; Huang T; Han G; Li Y; Yu H; Zhou J; Xu M;
Address:		"Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China. Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China. Analytical Instrumentation Center, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China. Institute of Medical Technology, Peking University Health Science Center, Beijing 100191, China. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China. Research Unit of Medinal Science Research Management/Basic and Clinical Research of Metabolic Cardiocascular Diseases, Chinese Academy of Medical Sciences, Beijing 100191, China"
Journal Title:		J Transl Int Med
Year:		2023
Volume:		20230328
Issue:		1
Page Number:		81 - 89
DOI:		10.2478/jtim-2022-0035
ISSN/ISBN:		2450-131X (Print) 2224-4018 (Electronic) 2224-4018 (Linking)
Abstract:		"OBJECTIVES: Childhood obesity affects multiple organs in the body and is associated with both significant morbidity and ultimately premature mortality. Childhood obesity, especially dyslipidemia, can lead to early atherosclerosis and premature cardiovascular disease (CVD) in adulthood. The detection of exhaled volatile organic compounds (VOCs) in the breath offers the opportunity for the discovery of novel disease-specific biomarkers. This study aimed to identify VOCs that correlate with childhood obesity accompanied by dyslipidemia. METHODS: A total of 82 overweight or obese children between the ages of 8 and 12 years were recruited from the exercise on obesity adolescents in Peking (EXCITING) study (NCT04984005). The breath VOCs of the participants were measured by gas chromatography-mass spectrometry (GC-MS). The classification was performed using principal component analysis (PCA) of the relative abundance of VOCs. The difference between the obese and overweight groups with or without dyslipidemia was analyzed. RESULTS: Among the 82 children, 25 were overweight, of whom 10 had dyslipidemia. The other 57 children were obese, and 17 of them had dyslipidemia. Obese children with dyslipidemia had higher triglycerides and elevated non-high-density lipoprotein-cholesterol compared to overweight children without dyslipidemia. We confirmed 13 compounds based on database well matches (average score > 80) for mass spectra and refractive index. These 13 VOCs were grouped into three chemical functional groups: saturated hydrocarbons, aromatic hydrocarbons and unsaturated aldehydes. For obese children with dyslipidemia, the PCA scatter plot of the three chemical groups was obviously separated from the other groups. Some of the candidates, including heptadecane, naphthalene, and cis-6-nonnenol, were significantly higher in obese children with dyslipidemia than in overweight groups with or without dyslipidemia. CONCLUSION: A suite of VOCs from three chemical function groups, saturated hydrocarbons, aromatic hydrocarbons, and unsaturated aldehydes, were separated in the obese children with dyslipidemia. Heptadecane, naphthalene, and cis-6-nonenol were significantly elevated in obese children with dyslipidemia. Our findings underscore the potential value of the candidate VOCs for future risk categorization"
Keywords:		childhood dyslipidemia obesity volatile organic compounds;
Notes:		"PubMed-not-MEDLINEXu, Tan Wang, Jiaxing Tan, Jiang Huang, Tao Han, Guojun Li, Yizhou Yu, Haiyi Zhou, Jiang Xu, Ming eng Poland 2023/05/24 J Transl Int Med. 2023 Mar 28; 11(1):81-89. doi: 10.2478/jtim-2022-0035. eCollection 2023 Mar"