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Neuron

Title:		Experience-Dependent Plasticity Drives Individual Differences in Pheromone-Sensing Neurons
Author(s):		Xu PS; Lee D; Holy TE;
Address:		"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63130, USA. Electronic address: xupei@wustl.edu. Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63130, USA. Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63130, USA. Electronic address: holy@wustl.edu"
Journal Title:		Neuron
Year:		2016
Volume:		91
Issue:		4
Page Number:		878 - 892
DOI:		10.1016/j.neuron.2016.07.034
ISSN/ISBN:		1097-4199 (Electronic) 0896-6273 (Print) 0896-6273 (Linking)
Abstract:		"Different individuals exhibit distinct behaviors, but studying the neuronal basis of individuality is a daunting challenge. Here, we considered this question in the vomeronasal organ, a pheromone-detecting epithelium containing hundreds of distinct neuronal types. Using light-sheet microscopy, we characterized in each animal the abundance of 17 physiologically defined types, altogether recording from half a million sensory neurons. Inter-animal differences were much larger than predicted by chance, and different physiological cell types showed distinct patterns of variability. One neuronal type was present in males and nearly absent in females. Surprisingly, this apparent sexual dimorphism was generated by plasticity, as exposure to female scents or single ligands led to both the elimination of this cell type and alterations in olfactory behavior. That an all-or-none apparent sex difference in neuronal types is controlled by experience-even in a sensory system devoted to 'innate' behaviors-highlights the extraordinary role of 'nurture' in neural individuality"
Keywords:		Animals Female Male Mice Neuronal Plasticity/*physiology Olfactory Perception/physiology Pheromones/*physiology Sensory Receptor Cells/*physiology Sex Characteristics Vomeronasal Organ/*cytology/physiology;
Notes:		"MedlineXu, Pei Sabrina Lee, Donghoon Holy, Timothy E eng DP1 OD006437/OD/NIH HHS/ R01 DC005964/DC/NIDCD NIH HHS/ R01 DC010381/DC/NIDCD NIH HHS/ R01 NS068409/NS/NINDS NIH HHS/ 2016/08/19 Neuron. 2016 Aug 17; 91(4):878-892. doi: 10.1016/j.neuron.2016.07.034"