| Title: | Diagnosis of Human Echinococcosis via Exhaled Breath Analysis: A Promise for Rapid Diagnosis of Infectious Diseases Caused by Helminths |
| Author(s): | Welearegay TG; Diouani MF; Osterlund L; Borys S; Khaled S; Smadhi H; Ionescu F; Bouchekoua M; Aloui D; Laouini D; Cindemir U; Ionescu R; |
| Address: | "Department of Electronics, Electrical and Automatic Engineering, Rovira i Virgili University, Tarragona, Spain. Laboratory of Epidemiology and Veterinary Microbiology, Institut Pasteur de Tunis, University Tunis El Manar, Tunis-Belvedere, Tunisia. Molecular Fingerprint AB Sweden, Uppsala. Angstrom Laboratory, Division of Solid State Physics, Department of Engineering Sciences, Uppsala University, Sweden. University Centre of Maritime and Tropical Medicine, Gdynia-Redlowo, Poland. Parasitology-Mycology Laboratory, Charles Nicolle Hospital, Tunis. Ibn Nafis Pneumology Department, Abderrahman Mami Hospital, Ariana. Laboratory of Transmission, Control and Immunobiology of Infections. Institute of Macromolecular Chemistry 'Petru Poni', Iasi, Romania" |
| ISSN/ISBN: | 1537-6613 (Electronic) 0022-1899 (Linking) |
| Abstract: | "BACKGROUND: Human echinococcosis is a neglected infectious disease affecting more than 1 million people globally. Its diagnosis is expensive and difficult because of lack of adequate resources in low-resource locations, where most cases occur. METHODS: A group of volunteers diagnosed with the 2 main types of echinococcosis and corresponding control groups were recruited from hospitals in Tunisia (32 patients with cystic echinococcosis and 43 controls) and Poland (16 patients with alveolar echinococcosis and 8 controls). Breath samples were collected from all patients and analyzed by gas chromatography coupled to mass spectrometry, and a specifically developed electronic nose system. RESULTS: The chemical analysis revealed statistically different concentrations of 2 compounds in the breath of patients with cystic echinococcosis compared to controls, and statistically different concentrations of 7 compounds in the breath of patients with alveolar echinococcosis compared to controls. The discrimination accuracy achieved by the electronic nose system was 100% for cystic echinococcosis and 92.9% for alveolar echinococcosis, while the discrimination accuracy between these 2 patient groups was 92.1%. CONCLUSION: Here we advocate a noninvasive, fast, easy-to-operate and nonexpensive diagnostic tool for the diagnosis of human echinococcosis disease through exhaled breath analysis, suitable for early diagnosis and population screening" |
| Keywords: | Adolescent Adult Animals Biomarkers/analysis/chemistry Breath Tests/instrumentation/*methods Echinococcosis/*diagnosis Electrochemical Techniques/instrumentation/*methods Electronic Nose *Exhalation Female Helminthiasis/diagnosis Helminths/pathogenicity H; |
| Notes: | "MedlineWelearegay, Tesfalem Geremariam Diouani, Mohamed Fethi Osterlund, Lars Borys, Sebastian Khaled, Samira Smadhi, Hanen Ionescu, Florina Bouchekoua, Meriam Aloui, Dorsaf Laouini, Dhafer Cindemir, Umut Ionescu, Radu eng Research Support, Non-U.S. Gov't 2018/07/18 J Infect Dis. 2019 Jan 1; 219(1):101-109. doi: 10.1093/infdis/jiy449" |
