| Title: | Emerging plasmid-encoded antisense RNA regulated systems |
| Address: | "Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069, USA. kweaver@usd.edu" |
| DOI: | 10.1016/j.mib.2007.03.002 |
| ISSN/ISBN: | 1369-5274 (Print) 1369-5274 (Linking) |
| Abstract: | Classic antisense RNA research has focused on detailed examination of a few plasmid-encoded systems whilst more recent efforts have focused on chromosomally encoded small RNAs. Recent work on newly identified plasmid-encoded antisense RNAs suggest that there is still much to learn from them about the versatility of regulatory RNAs. The alpha-proteobacterial repABC plasmids produce an antisense RNA that regulates the replication initiator independently of the partition proteins encoded in the same operon. The Staphylococcus aureus plasmid pSK41 produces an antisense RNA that regulates the replication initiator protein by a translational attenuation mechanism. Enterococcus faecalis pheromone-responsive plasmids produce plasmid-specific variants of an antisense RNA that regulates conjugation structural genes by a transcriptional attenuation mechanism. E. faecalis plasmid pAD1 encodes an antisense RNA-regulated addiction module that combines features of classic plasmid-encoded and trans-regulated chromosomally encoded antisense systems. Studies on these systems will expand our understanding of the repertoire of small RNA regulators |
| Keywords: | "Bacteria/*genetics/metabolism Conjugation, Genetic Gram-Positive Bacteria/genetics/metabolism Plasmids/*genetics RNA, Antisense/genetics/*metabolism RNA, Bacterial/*genetics Staphylococcus aureus/genetics/metabolism;" |
| Notes: | "MedlineWeaver, Keith E eng Review England 2007/03/23 Curr Opin Microbiol. 2007 Apr; 10(2):110-6. doi: 10.1016/j.mib.2007.03.002. Epub 2007 Mar 21" |
