| Title: | Fumonisin B(1) induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet |
| Author(s): | Voss KA; Riley RT; Gelineau-van Waes J; |
| Address: | "Toxicology and Mycotoxin Research Unit, Agricultural Research Service, USDA, Athens, GA, USA" |
| ISSN/ISBN: | 1613-4133 (Electronic) 1613-4125 (Linking) |
| Abstract: | "SCOPE: Fumonisin B1 (FB1 ) is found in corn-based foods and is a possible risk factor for neural tube defects (NTDs). The mechanism(s) underlying NTD induction by FB1 in LM/Bc mice is not understood; however, evidence suggests disrupted folate transport is involved. METHODS AND RESULTS: Female LM/Bc mice were fed folate-sufficient (control) or folate-deficient diet beginning 5 wk before mating, treated with 0 (vehicle), 2.5 or 10 mg/kg FB1 by intraperitoneal injection on embryonic days 7 (E7) and E8, and their fetuses examined on E16. Dose-dependent NTD induction was found in groups fed the control diet: 3 of 13 low-dose and 10 of 11 high-dose litters were affected. Among groups fed folate-deficient diet, NTDs were found only in 4 of 11 high-dose litters. In another trial, consumption of folate-deficient diet also resulted in fewer NTDs at a dose of 10 mg/kg FB1 and reduced maternal red blood cell folate levels by 80%. In utero death did not fully account for the differences in NTD rates. CONCLUSION: Folate deficiency does not exacerbate NTD induction by FB1 in LM/Bc mice. Interactions between folate, other nutritional factors, and FB1 in this mouse model for NTDs are complex and require further investigation" |
| Keywords: | "Animals Diet Disease Models, Animal Erythrocytes/chemistry Female Folic Acid/administration & dosage/*blood Folic Acid Deficiency/pathology Fumonisins/*toxicity *Maternal Nutritional Physiological Phenomena Mice Mice, Inbred Strains Neural Tube Defects/ch;" |
| Notes: | "MedlineVoss, Kenneth A Riley, Ronald T Gelineau-van Waes, Janee eng Germany 2014/03/04 Mol Nutr Food Res. 2014 Jun; 58(6):1190-8. doi: 10.1002/mnfr.201300720. Epub 2014 Feb 28" |
