| Title: | Association between exhaled inflammatory markers and asthma control in children |
| Author(s): | Van Vliet D; Smolinska A; Jobsis Q; Rosias PP; Muris JW; Dallinga JW; van Schooten FJ; Dompeling E; |
| Address: | "Department of Paediatric Pulmonology, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre (MUMC+), Maastricht, The Netherlands. Co-first authors" |
| DOI: | 10.1088/1752-7155/10/1/016014 |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "The relationship between exhaled inflammatory markers and asthma control in children is unclear. To explore the association between inflammatory markers in exhaled breath (fractional nitric oxide (FeNO), volatile organic compounds (VOCs), cytokines/chemokines) and asthma control. To assess whether exhaled inflammatory markers are able to discriminate between children with persistently controlled/uncontrolled asthma. 96 asthmatic children were followed-up in a one-year observational study. Every 2 months, the following parameters were assessed: asthma control, FeNO, lung function (forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), exhaled VOCs, and cytokines/chemokines in exhaled breath condensate (EBC). Random Forest was used to analyse the relationship between exhaled inflammatory markers and asthma control. For each model, patients were randomly selected for a training set and validation set. To assess the accuracy of the classification models, receiver operating characteristic-curves (ROC-curves) were generated. No significant association was found between the exhaled inflammatory markers (FeNO, markers in EBC, VOCs) and asthma control (area under the ROC-curve 49%). However, 15 exhaled VOCs could discriminate between subgroups of children with persistently controlled and uncontrolled asthma during all clinical visits (area under the ROC-curve 86%). Adding FeNO and markers in EBC to this model, did not lead to a more accurate classification (area under the ROC-curve 87%). There was no association between exhaled inflammatory markers and asthma control in children. However, children with persistently controlled or uncontrolled asthma during the 12 month study period could be discriminated by a set of VOCs" |
| Keywords: | Adolescent Anti-Asthmatic Agents/therapeutic use Asthma/drug therapy/*physiopathology Biomarkers/analysis *Breath Tests Child Cytokines/*analysis Exhalation Female Forced Expiratory Volume/physiology Humans Inflammation/physiopathology Male Nitric Oxide T; |
| Notes: | "MedlineVan Vliet, D Smolinska, A Jobsis, Q Rosias, P P R Muris, J W M Dallinga, J W van Schooten, F J Dompeling, E eng England 2016/02/20 J Breath Res. 2016 Feb 19; 10(1):016014. doi: 10.1088/1752-7155/10/1/016014" |
