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J Neurogenet

Title:		Behavioral and pheromonal phenotypes associated with expression of loss-of-function mutations in the sex-lethal gene of Drosophila melanogaster
Author(s):		Tompkins L; McRobert SP;
Address:		"Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA"
Journal Title:		J Neurogenet
Year:		1995
Volume:		9
Issue:		4
Page Number:		219 - 226
DOI:		10.3109/01677069509084158
ISSN/ISBN:		0167-7063 (Print) 0167-7063 (Linking)
Abstract:		"We have shown that female-specific functions of the sex determination gene Sex-lethal (Sxl) regulate sexual behavior and synthesis of the three major sex pheromones that have been identified in normal, sexually mature Drosophilia melanogaster males and virgin females. Diplo-X flies, heterozygous in trans for two partial loss-of-function Sxl mutations, elicit less courtship than normal females and produce large quantities of the inhibitory pheromones that normal males synthesize. In addition, the mutant flies fail to synthesize the female-predominant aphrodisiac pheromone or make very small quantities of this compound"
Keywords:		"Animals Drosophila melanogaster/*genetics Female *Genes, Insect *Genes, Lethal Male Mutation Phenotype Sex Attractants/*biosynthesis Sex Characteristics *Sex Determination Analysis Sexual Behavior, Animal/*physiology;"
Notes:		"MedlineTompkins, L McRobert, S P eng GM33511/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1995/02/01 J Neurogenet. 1995 Feb; 9(4):219-26. doi: 10.3109/01677069509084158"