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Biol Pharm Bull

Title:		Increases in plasma concentration of progesterone by protease-sensitive urinary pheromones in female rats
Author(s):		Tomioka M; Murayama T; Kashiwayanagi M;
Address:		"Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan"
Journal Title:		Biol Pharm Bull
Year:		2005
Volume:		28
Issue:		9
Page Number:		1770 - 1772
DOI:		10.1248/bpb.28.1770
ISSN/ISBN:		0918-6158 (Print) 0918-6158 (Linking)
Abstract:		Plasma progesterone concentrations in female Wistar rats after exposure to urine preparations with and without protease-treatment were measured to explore the effects of protease-sensitive pheromones on the endocrine state. Exposure to crude urine excreted from male rats induced an increase in the plasma progesterone concentration in female rats. The progesterone concentration of oestrous females increased with an increase in the protein concentration in urine samples. Exposure of females in the oestrous state to urine preparations treated with protease did not induce increases in plasma progesterone. These results suggest that the presence of a protease-sensitive component in male urine exerts an influence on the endocrine state of oestrous females
Keywords:		"Animals Estrous Cycle/physiology Female Peptide Hydrolases/*chemistry Pheromones/chemistry/*pharmacology/urine Progesterone/*blood Pronase/chemistry Rats Rats, Wistar Vomeronasal Organ/drug effects;"
Notes:		"MedlineTomioka, Mayumi Murayama, Toshihiko Kashiwayanagi, Makoto eng Research Support, Non-U.S. Gov't Japan 2005/09/06 Biol Pharm Bull. 2005 Sep; 28(9):1770-2. doi: 10.1248/bpb.28.1770"