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Biosensors (Basel)

Title:		Breath Analysis Using eNose and Ion Mobility Technology to Diagnose Inflammatory Bowel Disease-A Pilot Study
Author(s):		Tiele A; Wicaksono A; Kansara J; Arasaradnam RP; Covington JA;
Address:		"School of Engineering, University of Warwick, Coventry CV4 7AL, UK. F-A.Tiele@warwick.ac.uk. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. A.Wicaksono@warwick.ac.uk. Department of Gastroenterology, University Hospitals Coventry and Warwickshire, Coventry CV2 2DX, UK. Jiten.Kansara@uhcw.nhs.uk. Department of Gastroenterology, University Hospitals Coventry and Warwickshire, Coventry CV2 2DX, UK. R.Arasaradnam@warwick.ac.uk. Applied Biological Sciences, Coventry University, Coventry CV1 5FB, UK. R.Arasaradnam@warwick.ac.uk. Health and Life Sciences, University of Leicester, Leicester LE1 7RH, UK. R.Arasaradnam@warwick.ac.uk. Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. R.Arasaradnam@warwick.ac.uk. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. J.A.Covington@warwick.ac.uk"
Journal Title:		Biosensors (Basel)
Year:		2019
Volume:		20190412
Issue:		2
Page Number:		-
DOI:		10.3390/bios9020055
ISSN/ISBN:		2079-6374 (Electronic) 2079-6374 (Linking)
Abstract:		"Early diagnosis of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains a clinical challenge with current tests being invasive and costly. The analysis of volatile organic compounds (VOCs) in exhaled breath and biomarkers in stool (faecal calprotectin (FCP)) show increasing potential as non-invasive diagnostic tools. The aim of this pilot study is to evaluate the efficacy of breath analysis and determine if FCP can be used as an additional non-invasive parameter to supplement breath results, for the diagnosis of IBD. Thirty-nine subjects were recruited (14 CD, 16 UC, 9 controls). Breath samples were analysed using an in-house built electronic nose (Wolf eNose) and commercial gas chromatograph-ion mobility spectrometer (G.A.S. BreathSpec GC-IMS). Both technologies could consistently separate IBD and controls [AUC +/- 95%, sensitivity, specificity], eNose: [0.81, 0.67, 0.89]; GC-IMS: [0.93, 0.87, 0.89]. Furthermore, we could separate CD from UC, eNose: [0.88, 0.71, 0.88]; GC-IMS: [0.71, 0.86, 0.62]. Including FCP did not improve distinction between CD vs UC; eNose: [0.74, 1.00, 0.56], but rather, improved separation of CD vs controls and UC vs controls; eNose: [0.77, 0.55, 1.00] and [0.72, 0.89, 0.67] without FCP, [0.81, 0.73, 0.78] and [0.90, 1.00, 0.78] with FCP, respectively. These results confirm the utility of breath analysis to distinguish between IBD-related diagnostic groups. FCP does not add significant diagnostic value to breath analysis within this study"
Keywords:		Adult Biosensing Techniques/instrumentation/*methods Breath Tests/instrumentation/methods Electronic Nose/*standards Exhalation Female Humans Inflammatory Bowel Diseases/*diagnosis Male Middle Aged Volatile Organic Compounds/*analysis Gc-ims Inflammatory;
Notes:		"MedlineTiele, Akira Wicaksono, Alfian Kansara, Jiten Arasaradnam, Ramesh P Covington, James A eng Switzerland 2019/04/25 Biosensors (Basel). 2019 Apr 12; 9(2):55. doi: 10.3390/bios9020055"