| Title: | Breathomics in the setting of asthma and chronic obstructive pulmonary disease |
| Author(s): | Bos LD; Sterk PJ; Fowler SJ; |
| Address: | "Department of Respiratory Medicine and Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Electronic address: l.d.bos@amc.nl. Department of Respiratory Medicine and Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. Centre for Respiratory Medicine and Allergy, University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom" |
| DOI: | 10.1016/j.jaci.2016.08.004 |
| ISSN/ISBN: | 1097-6825 (Electronic) 0091-6749 (Linking) |
| Abstract: | "Exhaled breath contains thousands of volatile organic compounds that reflect the metabolic process occurring in the host both locally in the airways and systemically. They also arise from the environment and airway microbiome. Comprehensive analysis of breath volatile organic compounds (breathomics) provides opportunities for noninvasive biomarker discovery and novel mechanistic insights. Applications in patients with obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease, include not only diagnostics (especially in children and other challenging diagnostic areas) but also identification of clinical treatable traits, such as airway eosinophilia and risk of infection/exacerbation, that are not specific to diagnostic labels. Although many aspects of breath sampling and analysis are challenging, proof-of-concept studies with mass spectrometry and electronic nose technologies have provided independent studies with moderate-to-good diagnostic and phenotypic accuracies. The present review evaluates the data obtained by using breathomics in (1) predicting the inception of asthma or chronic obstructive pulmonary disease, (2) inflammatory phenotyping, (3) exacerbation prediction, and (4) treatment stratification. The current findings merit the current efforts of large multicenter studies using standardized sampling, shared analytic methods, and databases, including external validation cohorts. This will position this noninvasive technology in the clinical assessment and monitoring of chronic airways diseases" |
| Keywords: | "Asthma/*diagnosis/*physiopathology *Breath Tests Humans Predictive Value of Tests Pulmonary Disease, Chronic Obstructive/*diagnosis/*physiopathology Reference Standards Volatile Organic Compounds/*analysis Asthma Breathomics breath analysis chronic obstru;" |
| Notes: | "MedlineBos, Lieuwe D Sterk, Peter J Fowler, Stephen J eng Research Support, Non-U.S. Gov't Review 2016/09/04 J Allergy Clin Immunol. 2016 Oct; 138(4):970-976. doi: 10.1016/j.jaci.2016.08.004. Epub 2016 Aug 31" |
