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Biochem Biophys Res Commun

Title:		An altered adenylate cyclase in cdc35-1 cell division cycle mutant of yeast
Author(s):		Sy J; Tamai Y;
Address:
Journal Title:		Biochem Biophys Res Commun
Year:		1986
Volume:		140
Issue:		2
Page Number:		723 - 727
DOI:		10.1016/0006-291x(86)90791-6
ISSN/ISBN:		0006-291X (Print) 0006-291X (Linking)
Abstract:		"Adenylate cyclase activity was studied in Saccharomyces cerevisiae's cell division cycle (cdc) mutant 35-1. The temperature sensitive mutant cdc35-1 was previously mapped as an allele of cyr, the adenylate cyclase gene. However, the adenylate cyclase activities of membranes prepared from cdc35-1 were not thermosensitive. The adenylate cyclase activity of cdc35-1 was found to have an altered Mn2+ dependency and did not respond to Gpp(NH)p stimulation. These results suggest that cdc35-1 mutation may not be at the catalytic site but at a site where adenylate cyclase interacts with regulatory proteins"
Keywords:		Adenylyl Cyclases/genetics/*metabolism Binding Sites Catalysis Cell Cycle Cell Division Guanylyl Imidodiphosphate/pharmacology Manganese/pharmacology Mating Factor Mutation Peptides/pharmacology Saccharomyces cerevisiae/*enzymology/genetics Temperature;
Notes:		"MedlineSy, J Tamai, Y eng Research Support, U.S. Gov't, Non-P.H.S. 1986/10/30 Biochem Biophys Res Commun. 1986 Oct 30; 140(2):723-7. doi: 10.1016/0006-291x(86)90791-6"