| Title: | The Genetics of Male Pheromone Preference Difference Between Drosophila melanogaster and Drosophila simulans |
| Author(s): | Shahandeh MP; Pischedda A; Rodriguez JM; Turner TL; |
| Address: | "Dept. of Ecology, Evolution, and Marine Biology, University of California Santa Barbara and mshahandeh@ucsb.edu. Department of Biology, Barnard College, Columbia University, New York 10027. Dept. of Ecology, Evolution, and Marine Biology, University of California Santa Barbara and" |
| ISSN/ISBN: | 2160-1836 (Electronic) 2160-1836 (Linking) |
| Abstract: | "Species of flies in the genus Drosophila differ dramatically in their preferences for mates, but little is known about the genetic or neurological underpinnings of this evolution. Recent advances have been made to our understanding of one case: pheromone preference evolution between the species D. melanogaster and D. simulans Males of both species are very sensitive to the pheromone 7,11-HD that is present only on the cuticle of female D. melanogaster In one species this cue activates courtship, and in the other it represses it. This change in valence was recently shown to result from the modification of central processing neurons, rather than changes in peripherally expressed receptors, but nothing is known about the genetic changes that are responsible. In the current study, we show that a 1.35 Mb locus on the X chromosome has a major effect on male 7,11-HD preference. Unfortunately, when this locus is divided, the effect is largely lost. We instead attempt to filter the 159 genes within this region using our newfound understanding of the neuronal underpinnings of this phenotype to identify and test candidate genes. We present the results of these tests, and discuss the difficulty of identifying the genetic architecture of behavioral traits and the potential of connecting these genetic changes to the neuronal modifications that elicit different behaviors" |
| Keywords: | "Alkadienes/*metabolism Animals Drosophila/*genetics/physiology *Evolution, Molecular Female *Genetic Loci Male *Mating Preference, Animal Sex Attractants/*metabolism X Chromosome/genetics behavioral genetics courtship behavior male mate choice pheromones;" |
| Notes: | "MedlineShahandeh, Michael P Pischedda, Alison Rodriguez, Jason M Turner, Thomas L eng R01 GM098614/GM/NIGMS NIH HHS/ P40 OD018537/OD/NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2019/11/22 G3 (Bethesda). 2020 Jan 7; 10(1):401-415. doi: 10.1534/g3.119.400780" |
