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J Liposome Res

Title:		Large-scale preparation of clove essential oil and eugenol-loaded liposomes using a membrane contactor and a pilot plant
Author(s):		Sebaaly C; Greige-Gerges H; Agusti G; Fessi H; Charcosset C;
Address:		"a Bioactive Molecules Research Group, Department of Chemistry and Biochemistry, Faculty of Sciences 2, PRASE, Doctoral School of Sciences and Technologies, Lebanese University , Lebanon and. b Laboratoire d'Automatique et de Genie des Procedes (LAGEP), UMR-CNRS 5007 , Universite Claude Bernard Lyon 1 , CPE Lyon , Villeurbanne Cedex , France"
Journal Title:		J Liposome Res
Year:		2016
Volume:		20150623
Issue:		2
Page Number:		126 - 138
DOI:		10.3109/08982104.2015.1057849
ISSN/ISBN:		1532-2394 (Electronic) 0898-2104 (Linking)
Abstract:		"Based on our previous study where optimal conditions were defined to encapsulate clove essential oil (CEO) into liposomes at laboratory scale, we scaled-up the preparation of CEO and eugenol (Eug)-loaded liposomes using a membrane contactor (600 mL) and a pilot plant (3 L) based on the principle of ethanol injection method, both equipped with a Shirasu Porous Glass membrane for injection of the organic phase into the aqueous phase. Homogenous, stable, nanometric-sized and multilamellar liposomes with high phospholipid, Eug loading rates and encapsulation efficiency of CEO components were obtained. Saturation of phospholipids and drug concentration in the organic phase may control the liposome stability. Liposomes loaded with other hydrophobic volatile compounds could be prepared at large scale using the ethanol injection method and a membrane for injection"
Keywords:		*Biotechnology Clove Oil/*chemistry Eugenol/*chemistry *Liposomes Particle Size Pilot Projects Surface Properties Clove essential oil Lipoid S100 Phospholipon 90H eugenol liposomes membrane contactor membrane emulsification pilot scale up;
Notes:		"MedlineSebaaly, Carine Greige-Gerges, Helene Agusti, Geraldine Fessi, Hatem Charcosset, Catherine eng Research Support, Non-U.S. Gov't England 2015/06/24 J Liposome Res. 2016; 26(2):126-38. doi: 10.3109/08982104.2015.1057849. Epub 2015 Jun 23"