| Title: | Influence of carbon catabolite repression on the G1 arrest of Saccharomyces cerevisiae MATa cells by alpha factor |
| Author(s): | Ruiz T; Villanueva JR; Rodriguez L; |
| DOI: | 10.1099/00221287-130-2-337 |
| ISSN/ISBN: | 0022-1287 (Print) 0022-1287 (Linking) |
| Abstract: | "Cells of the yeast Saccharomyces cerevisiae of the a mating type were arrested at the G1 phase of the cell division cycle after treatment with alpha factor in a culture medium containing a high concentration (2%, w/v, or higher) of a catabolite-repressing sugar. In media containing either a lower concentration of sugar or a non-fermentable carbon source, the extent of G1 arrest induced by the pheromone was reduced or became undetectable. Under catabolite-derepressing conditions alpha factor was inactivated by a cells at a higher rate than that found in repressing media. These results indicate the existence of a close correlation between the action of alpha factor on a cells and conditions of catabolite repression or derepression. A joint mechanism of action of alpha factor and catabolite-repressing carbon sources on a cells is postulated" |
| Keywords: | Enzyme Repression Fructose/metabolism Glucose/metabolism Glycerol/metabolism Glycoside Hydrolases/metabolism Interphase/*drug effects Mating Factor Peptides/*pharmacology Pyruvates/metabolism Saccharomyces cerevisiae/*cytology/drug effects/metabolism beta; |
| Notes: | "MedlineRuiz, T Villanueva, J R Rodriguez, L eng Research Support, Non-U.S. Gov't England 1984/02/01 J Gen Microbiol. 1984 Feb; 130(2):337-42. doi: 10.1099/00221287-130-2-337" |
