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Future Oncol

Title:		Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose
Author(s):		Roine A; Tolvanen M; Sipilainen M; Kumpulainen P; Helenius MA; Lehtimaki T; Vepsalainen J; Keinanen TA; Hakkinen MR; Koskimaki J; Veskimae E; Tuokko A; Visakorpi T; Tammela TL; Sioris T; Paavonen T; Lekkala J; Helle H; Oksala NK;
Address:		"Medical School, University of Tampere, Tampere, Finland. antti.roine@uta.fi"
Journal Title:		Future Oncol
Year:		2012
Volume:		8
Issue:		9
Page Number:		1157 - 1165
DOI:		10.2217/fon.12.93
ISSN/ISBN:		1744-8301 (Electronic) 1479-6694 (Linking)
Abstract:		"AIM: To determine whether an electronic nose can differentiate cultured nonmalignant and malignant prostatic cells from each other and whether the smell print is secreted to the surrounding medium. MATERIALS & METHODS: Prostatic nonmalignant (EP-156T and controls) and malignant (LNCaP) cell lines, as well as conditioned and unconditioned media, were collected. The smell prints of the samples were analyzed by a ChemPro((R)) 100 electronic nose device. The data were normalized and dimension reduction was conducted. The samples were classified and misclassification rates were calculated. RESULTS: The electronic nose differentiated the nonmalignant and malignant cell lines from each other, achieving misclassification rates of 2.9-3.6%. Cells did not differ from the conditioned medium but differed from the unconditioned medium (misclassification rates: 0.0-25.6%). CONCLUSION: Malignant and nonmalignant prostatic cell lines have distinct smell prints. Prostatic cancer cells seem to modify the smell print of their medium"
Keywords:		"Cell Line, Tumor Culture Media, Conditioned/analysis/chemistry *Electronic Nose Humans Male Odorants/*analysis Prostate/*pathology Prostatic Neoplasms Volatile Organic Compounds/*analysis/chemistry/metabolism;"
Notes:		"MedlineRoine, Antti Tolvanen, Mikko Sipilainen, Miki Kumpulainen, Pekka Helenius, Merja A Lehtimaki, Terho Vepsalainen, Jouko Keinanen, Tuomo A Hakkinen, Merja R Koskimaki, Juha Veskimae, Erik Tuokko, Antti Visakorpi, Tapio Tammela, Teuvo L Sioris, Thanos Paavonen, Timo Lekkala, Jukka Helle, Hannu Oksala, Niku K J eng Research Support, Non-U.S. Gov't England 2012/10/04 Future Oncol. 2012 Sep; 8(9):1157-65. doi: 10.2217/fon.12.93"