| Title: | Chronic risk assessment of exposure to volatile organic compounds in the atmosphere near the largest Mediterranean industrial site |
| Author(s): | Ramirez N; Cuadras A; Rovira E; Borrull F; Marce RM; |
| Address: | "Department of Analytical Chemistry and Organic Chemistry, Universitat Rovira i Virgili, Marcel.li Domingo s/n, Sescelades Campus, Tarragona 43007, Spain" |
| DOI: | 10.1016/j.envint.2011.11.002 |
| ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Linking) |
| Abstract: | "This study focuses on characterising the risk of exposure to volatile organic compounds (VOCs) by means of inhalation in people living in the vicinity of the largest chemical production site in the Mediterranean area. Eighty-six VOCs were initially selected for this study based on their adverse environmental and health effects. The monitoring campaign was conducted for 276 days in three different locations around the chemical site. The analytical method used for the characterisation was based on European standard method EN-14662-2, which consists of the active sampling of air for 24h in charcoal tubes, followed by extraction with carbon disulphide and GC-MS analysis. Forty-four VOCs with toxicological data available concerning their carcinogenic and non-carcinogenic health effects were quantified during the monitoring campaign. None of the quantified VOCs showed average concentrations exceeding their chronic reference concentrations and, therefore, no non-carcinogenic health effects are expected as a result of this exposure. However, the global average cancer risk due to VOC exposure in the area (3.3x10(-4)) was found to be above the values recommended by the WHO and USEPA. The influence of the analytical method was also evaluated by comparing cancer risk estimates using a thermal desorption (TD) method based on method EN-14662-1. The results of the 24-h samples for the solvent extraction method were compared with the average of 12 daily samples of 2-h for the TD method for 24 sampling days. Although the global estimated lifetime cancer risk was statistically comparable for both methods, some differences were found in individual VOC risks. To our knowledge, this is the first study that estimates the carcinogenic and non-carcinogenic risks posed by the inhalation of VOCs in people living near a chemical site of this size, and compares the estimated cancer risk obtained using two different standard analytical methods" |
| Keywords: | Air Pollutants/analysis/*toxicity Air Pollution/statistics & numerical data Chemical Industry Environmental Exposure/*analysis/statistics & numerical data Humans Risk Assessment Spain Volatile Organic Compounds/analysis/*toxicity; |
| Notes: | "MedlineRamirez, Noelia Cuadras, Anna Rovira, Enric Borrull, Francesc Marce, Rosa Maria eng Research Support, Non-U.S. Gov't Netherlands 2012/01/03 Environ Int. 2012 Feb; 39(1):200-9. doi: 10.1016/j.envint.2011.11.002. Epub 2011 Dec 10" |
