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Science

Title:		Chemistry of pheromone and hormone metabolism in insects
Author(s):		Prestwich GD;
Address:
Journal Title:		Science
Year:		1987
Volume:		237
Issue:		4818
Page Number:		999 - 1006
DOI:		10.1126/science.3616631
ISSN/ISBN:		0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Chemical evidence is needed in both insect endocrinology and sensory physiology to understand hormone and pheromone action at the molecular level. Radiolabeled pheromones and hormones have been synthesized and used to identify binding and catabolic proteins from insect tissues. Chemically modified analogs, including photoaffinity labels and enzyme inhibitors, are among the tools used to covalently modify the specific acceptor or catalytic sites. Such targeted agents can also provide leads for the design of growth and mating disruptants by allowing manipulation of the physiologically important interactions of the chemical signals with macromolecules"
Keywords:		Animals Bees/metabolism Chemical Phenomena Chemistry Cockroaches/metabolism Female Insect Hormones/*metabolism Insecta/metabolism Juvenile Hormones/metabolism Male Methoprene/metabolism Moths/metabolism Pheromones/*metabolism;
Notes:		"MedlinePrestwich, G D eng GM-30899/GM/NIGMS NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 1987/08/28 Science. 1987 Aug 28; 237(4818):999-1006. doi: 10.1126/science.3616631"