| Title: | Members of a family of Drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs |
| Author(s): | Pikielny CW; Hasan G; Rouyer F; Rosbash M; |
| Address: | "Howard Hughes Institute, Brandeis University, Waltham, Massachusetts 02254" |
| DOI: | 10.1016/0896-6273(94)90150-3 |
| ISSN/ISBN: | 0896-6273 (Print) 0896-6273 (Linking) |
| Abstract: | "A polymerase chain reaction-based method was used to generate a Drosophila melanogaster antennal cDNA library from which head cDNAs were subtracted. We identified five cDNAs that code for antennal proteins containing six cysteines in a conserved pattern shared with known moth antennal proteins, including pheromone-binding proteins. Another cDNA codes for a protein related to vertebrate brain proteins that bind hydrophobic ligands. In all, we describe seven antennal proteins which contain potential signal peptides, suggesting that, like pheromone-binding proteins, they may be secreted in the lumen of olfactory hairs. The expression patterns of these putative odorant-binding proteins define at least four different subsets of olfactory hairs and suggest that the Drosophila olfactory apparatus is functionally segregated" |
| Keywords: | "Amino Acid Sequence Animals Base Sequence Cloning, Molecular DNA Primers DNA, Complementary/biosynthesis/metabolism Drosophila melanogaster/genetics/*metabolism Gene Expression Gene Library Molecular Sequence Data Multigene Family Odorants Olfactory Mucos;" |
| Notes: | "MedlinePikielny, C W Hasan, G Rouyer, F Rosbash, M eng Comparative Study 1994/01/01 Neuron. 1994 Jan; 12(1):35-49. doi: 10.1016/0896-6273(94)90150-3" |
