| Title: | "Migration of cyclohexanone and 3,3,5-trimethylcyclohexanone from a neonatal enteral feeding system into human milk" |
| Author(s): | Prazad P; Donovan R; Won B; Cortes D; |
| Address: | "Advocate Children's Hospital, Park Ridge, IL, USA. Preetha.prazad@aah.org. Advocate Children's Hospital, Park Ridge, IL, USA. Rosaland Franklin University of Medicine and Science, North Chicago, IL, USA. Stat Analysis Corporation, Chicago, IL, USA" |
| DOI: | 10.1038/s41372-021-01036-3 |
| ISSN/ISBN: | 1476-5543 (Electronic) 0743-8346 (Linking) |
| Abstract: | "OBJECTIVE: Estimate the migration of volatile organic compounds (VOCs) which have been identified by the EPA as a public health concern, from the enteral feeding system into human milk. STUDY DESIGN: Unfortified human milk samples were infused through an enteral feeding system with varying duration of infusion, incubator temperature, and pre-infusion tube priming. Purge & Trap analysis and GC/MS were used to identify the VOC profile of milk pre- and post-infusion. RESULT: Cyclohexanone and 3,3,5-trimethylcyclohexanone (3,3,5-TMC) accumulated significantly in milk samples post-infusion. Duration of infusion had a significant effect on VOC accumulation (p = 0.001). Accumulation patterns of cyclohexanone and 3,3,5-TMC differed significantly based on milk type (donor vs. mother's own milk). CONCLUSIONS: VOCs, migrate from plastic-based feeding equipment into human milk. Based on these findings, limiting the duration of feeding infusion would reduce VOC exposure derived from enteral feeding in the neonatal intensive care unit" |
| Keywords: | "*Cyclohexanones Enteral Nutrition Humans Infant, Newborn Intensive Care Units, Neonatal *Milk, Human;" |
| Notes: | "MedlinePrazad, Preetha Donovan, Ramona Won, Brian Cortes, Donald eng 2021/03/25 J Perinatol. 2021 May; 41(5):1074-1082. doi: 10.1038/s41372-021-01036-3. Epub 2021 Mar 23" |
