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Brain Struct Funct

Title:		Distribution of oxytocin and co-localization with arginine vasopressin in the brain of mice
Author(s):		Otero-Garcia M; Agustin-Pavon C; Lanuza E; Martinez-Garcia F;
Address:		"Departaments de Biologia Cel.lular i de Biologia Funcional, Facultat de Ciencies Biologiques, Universitat de Valencia, Valencia, Spain. Lab. of Functional Neuroanatomy (NeuroFun), Unitat Predepartamental de Medicina, Facultat de Ciencies de la Salut, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071, Castello de la Plana, Spain. Lab. of Functional Neuroanatomy (NeuroFun), Unitat Predepartamental de Medicina, Facultat de Ciencies de la Salut, Universitat Jaume I, Av. de Vicent Sos Baynat, s/n, 12071, Castello de la Plana, Spain. femartin@uji.es"
Journal Title:		Brain Struct Funct
Year:		2016
Volume:		20150920
Issue:		7
Page Number:		3445 - 3473
DOI:		10.1007/s00429-015-1111-y
ISSN/ISBN:		1863-2661 (Electronic) 1863-2653 (Linking)
Abstract:		"Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable OTergic cell group is found near the ventral bed nucleus of the stria terminalis (BST), distributed between the anterodorsal preoptic nucleus and the nucleus of anterior commissure (ADP/AC). This cell group, the rostral edge of the Pa and the periventricular hypothalamus display frequent OT + AVP double labelling, with a general dominance of OT over AVP immunoreactivity. Fibres with similar immunoreactivity profile innervate the accumbens shell and core, central amygdala and portions of the intervening BST. These data, together with data in the literature on rats, suggest that the projections of ADP/AC nonapeptidergic cells onto these brain centres could promote pup-motivated behaviours and inhibit pup avoidance during motherhood"
Keywords:		Animals Arginine Vasopressin/*metabolism Brain/cytology/*metabolism Female Mice Neurons/cytology/metabolism Neurophysins/metabolism Oxytocin/*metabolism Accumbens Amygdala Bed nucleus of the stria terminalis Maternal behaviour Neurosecretory cells Sociose;
Notes:		"MedlineOtero-Garcia, Marcos Agustin-Pavon, Carmen Lanuza, Enrique Martinez-Garcia, Fernando eng Research Support, Non-U.S. Gov't Germany 2015/09/22 Brain Struct Funct. 2016 Sep; 221(7):3445-73. doi: 10.1007/s00429-015-1111-y. Epub 2015 Sep 20"