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Nat Commun

Title:		Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans
Author(s):		Ohta A; Ujisawa T; Sonoda S; Kuhara A;
Address:		"1] Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan [2]. Laboratory of Molecular and Cellular Regulation, Faculty of Science and Engineering, Institute for Integrative Neurobiology, Konan University, 8-9-1 Okamoto, Higashinada-ku, Kobe 658-8501, Japan"
Journal Title:		Nat Commun
Year:		2014
Volume:		20140722
Issue:
Page Number:		4412 -
DOI:		10.1038/ncomms5412
ISSN/ISBN:		2041-1723 (Electronic) 2041-1723 (Linking)
Abstract:		"Temperature is a critical environmental stimulus that has a strong impact on an organism's biochemistry. Animals can respond to changes in ambient temperature through behaviour or altered physiology. However, how animals habituate to temperature is poorly understood. The nematode C. elegans stores temperature experiences and can induce temperature habituation-linked cold tolerance. Here we show that light and pheromone-sensing neurons (ASJ) regulate cold habituation through insulin signalling. Calcium imaging reveals that ASJ neurons respond to temperature. Cold habituation is abnormal in a mutant with impaired cGMP signalling in ASJ neurons. Insulin released from ASJ neurons is received by the intestine and neurons regulating gene expression for cold habituation. Thus, temperature sensation in a light and pheromone-sensing neuron produces a robust effect on insulin signalling that controls experience-dependent temperature habituation"
Keywords:		"Adaptation, Physiological Animals Animals, Genetically Modified Caenorhabditis elegans/genetics/*physiology Caenorhabditis elegans Proteins/genetics/metabolism Calcium/analysis/metabolism Cold Temperature Cold-Shock Response Gene Expression Regulation Ins;"
Notes:		"MedlineOhta, Akane Ujisawa, Tomoyo Sonoda, Satoru Kuhara, Atsushi eng Research Support, Non-U.S. Gov't England 2014/07/23 Nat Commun. 2014 Jul 22; 5:4412. doi: 10.1038/ncomms5412"