| Title: | "Gut microbial activity, implications for health and disease: the potential role of metabolite analysis" |
| Author(s): | Nyangale EP; Mottram DS; Gibson GR; |
| Address: | "The University of Reading, Food and Nutritional Sciences, Whiteknights, PO Box 226, Reading RG6 6AP, United Kingdom. e.p.nyangale@reading.ac.uk" |
| ISSN/ISBN: | 1535-3907 (Electronic) 1535-3893 (Linking) |
| Abstract: | "Microbial metabolism of proteins and amino acids by human gut bacteria generates a variety of compounds including phenol, indole, and sulfur compounds and branched chain fatty acids, many of which have been shown to elicit a toxic effect on the lumen. Bacterial fermentation of amino acids and proteins occurs mainly in the distal colon, a site that is often fraught with symptoms from disorders including ulcerative colitis (UC) and colorectal cancer (CRC). In contrast to carbohydrate metabolism by the gut microbiota, proteolysis is less extensively researched. Many metabolites are low molecular weight, volatile compounds. This review will summarize the use of analytical methods to detect and identify compounds in order to elucidate the relationship between specific dietary proteinaceous substrates, their corresponding metabolites, and implications for gastrointestinal health" |
| Keywords: | "Amino Acids/chemistry Animals Bacteria/chemistry/*growth & development Biomarkers/analysis Colorectal Neoplasms/chemistry/microbiology/pathology Diet, High-Fat/adverse effects Dietary Proteins/adverse effects Feces/chemistry Gastrointestinal Tract/chemist;" |
| Notes: | "MedlineNyangale, Edna P Mottram, Donald S Gibson, Glenn R eng Review 2012/11/03 J Proteome Res. 2012 Dec 7; 11(12):5573-85. doi: 10.1021/pr300637d. Epub 2012 Nov 1" |
