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J Chromatogr B Biomed Sci Appl

Title:		Headspace solid-phase microextraction profiling of volatile compounds in urine: application to metabolic investigations
Author(s):		Mills GA; Walker V;
Address:		"School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK"
Journal Title:		J Chromatogr B Biomed Sci Appl
Year:		2001
Volume:		753
Issue:		2
Page Number:		259 - 268
DOI:		10.1016/s0378-4347(00)00554-5
ISSN/ISBN:		1387-2273 (Print) 1387-2273 (Linking)
Abstract:		"Volatile compounds contribute substantially to the metabolic pool in man. Their analysis in body fluids is problematic. We investigated headspace solid-phase microextraction (HS-SPME) with Carboxen-polydimethylsiloxane fibres and gas chromatography-mass spectrometry for profiling urinary volatile components. These fibres were more sensitive for very volatile and sulfur compounds than three other phases tested. We detected a wide range of compounds in normal urine at acid and alkaline pH. Profiles presented for five individuals with metabolic disturbances demonstrate abnormal accumulation of sulfur compounds, fatty acids and plasticisers. HS-SPME can complement profiling of non-volatile compounds in metabolic investigations and could be a useful extension of the diagnostic repertoire"
Keywords:		"Adult Chemical and Drug Induced Liver Injury/urine Child, Preschool Female Gas Chromatography-Mass Spectrometry/*methods Humans Infant, Newborn Male Metabolism, Inborn Errors/urine Middle Aged Organic Chemicals/*urine Volatilization;"
Notes:		"MedlineMills, G A Walker, V eng Case Reports Netherlands 2001/05/04 J Chromatogr B Biomed Sci Appl. 2001 Apr 5; 753(2):259-68. doi: 10.1016/s0378-4347(00)00554-5"