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Arh Hig Rada Toksikol

Title:		How volatile organic compounds affect free radical and antioxidant enzyme activity in textile workers
Author(s):		Bayil S; Cicek H; Cimenci IG; Hazar M;
Address:		"Vocational School of Higher Education for Health Services, University of Gaziantep, Gaziantep, Turkey. bayil@gantep.edu.tr"
Journal Title:		Arh Hig Rada Toksikol
Year:		2008
Volume:		59
Issue:		4
Page Number:		283 - 287
DOI:		10.2478/10004-1254-59-2008-1918
ISSN/ISBN:		1848-6312 (Electronic) 0004-1254 (Linking)
Abstract:		"Various effects of exposure to volatile organic compounds (VOC) have recently become an important issue because of their widespread use in industry. The aim of this study was to determine the effect of volatile organic solvents commonly used in textile paint industry on free radical levels and the antioxidant enzyme system in textile workers. The study included twenty exposed workers and twenty controls. Blood samples were taken after an overnight fast of 10 to 12 hours. Malondialdehyde (MDA) and total antioxidant capacity (TAC) were studied in serum while super oxide dismutase (SOD) activity was studied in erythrocytes. Statistical analysis was performed using the ANOVA and Kruskall-Wallis analysis tests. MDA and SOD were significantly higher in textile workers than in controls (p<0.01). In contrast, no significant difference was observed between them for TAC (p>0.05).Elevated MDA levels in textile workers may indicate increased lipid peroxidation as a result of long-term exposure to organic solvents, whereas elevated SOD activity suggests that the antioxidant system was activated to counter lipid peroxidation. The results suggest that textile workers occupationally exposed to volatile organic solvents make a risk group and require more frequent periodic examinations"
Keywords:		Adult Antioxidants/*metabolism Free Radicals/metabolism Humans *Lipid Peroxidation Male Malondialdehyde/*blood *Occupational Exposure Superoxide Dismutase/*blood *Textile Industry Volatile Organic Compounds/*adverse effects;
Notes:		"MedlineBayil, Sibel Cicek, Hulya Cimenci, Iclal Geyikli Hazar, Muhsin eng Croatia 2008/12/10 Arh Hig Rada Toksikol. 2008 Dec; 59(4):283-7. doi: 10.2478/10004-1254-59-2008-1918"