| Title: | Cholinergic neurons mediate CaMKII-dependent enhancement of courtship suppression |
| Address: | "Brandeis University, Department of Biology and Volen Center for Complex Systems, Waltham, Massachusetts 02454-9110, USA" |
| ISSN/ISBN: | 1072-0502 (Print) 1072-0502 (Linking) |
| Abstract: | "In Drosophila, calcium/calmodulin-dependent protein kinase II (CaMKII) activity is crucial in associative courtship conditioning for both memory formation and suppression of courtship during training with a mated female. We have previously shown that increasing levels of constitutively active CaMKII, but not calcium-dependent CaMKII, in a subset of neurons can decrease the initial level of courtship and enhance the rate of suppression of courtship in response to a mated female. In this study, we demonstrate that a subpopulation of noncholinergic, nondopaminergic, non-GABAergic neurons can cause CaMKII-dependent reductions in initial courtship, but only cholinergic neurons enhance training-dependent suppression. These data suggest that processing of pheromonal signals in two subpopulations of neurons, likely antennal lobe projection neurons, is critical for behavioral plasticity" |
| Keywords: | "Adaptation, Psychological Analysis of Variance Animals Animals, Genetically Modified Association Learning/*physiology Calcium/metabolism Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases/classification/genetic;" |
| Notes: | "MedlineMehren, Jennifer E Griffith, Leslie C eng P01 NS44232/NS/NINDS NIH HHS/ P30 NS045713/NS/NINDS NIH HHS/ S10 RR16780/RR/NCRR NIH HHS/ F32 NS43024/NS/NINDS NIH HHS/ R01 GM054408-11/GM/NIGMS NIH HHS/ R01 GM054408/GM/NIGMS NIH HHS/ Comparative Study Research Support, N.I.H., Extramural 2006/11/15 Learn Mem. 2006 Nov-Dec; 13(6):686-9. doi: 10.1101/lm.317806. Epub 2006 Nov 13" |
