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J Nutr Metab

Title:		Evaluation of Antioxidant Capacity of Solanum sessiliflorum (Cubiu) Extract: An In Vitro Assay
Author(s):		Mascato DR; Monteiro JB; Passarinho MM; Galeno DM; Cruz RJ; Ortiz C; Morales L; Lima ES; Carvalho RP;
Address:		"Programa Multi-Institucional de Pos-Graduacao em Biotecnologia, Universidade Federal do Amazonas, 69077-000 Manaus, AM, Brazil. Division of Biochemistry, Ponce Health Sciences University, School of Medicine, Ponce Research Institute, Ponce, PR 00732-7004, USA. Biology Department, University of Puerto Rico at Ponce, Ponce, PR 00734, USA. Divisions of Pharmacology & Toxicology & Cancer Biology, Ponce Health Sciences University, School of Medicine, Ponce Research Institute, Ponce, PR 00732-7004, USA. Public Health Program, Ponce Health Sciences University, Ponce, PR 00732-7004, USA. Faculdade de Ciencias Farmaceuticas, Universidade Federal do Amazonas, 69010-300 Manaus, AM, Brazil"
Journal Title:		J Nutr Metab
Year:		2015
Volume:		20151215
Issue:
Page Number:		364185 -
DOI:		10.1155/2015/364185
ISSN/ISBN:		2090-0724 (Print) 2090-0732 (Electronic) 2090-0724 (Linking)
Abstract:		"Cubiu is a vegetable of Solanaceae family, native to the Amazon, which is widely distributed through Brazil, Peru, and Colombia. It is used in food, medicine, and cosmetics by native populations. Research has shown that cubiu extracts have antioxidant activities with great biological relevance. We performed a phytochemical screening to identify the main chemical groups that could confer antioxidant activity to this extract. Several tests and qualitative precipitation specific staining for major classes of secondary metabolites were used. Antioxidant capacity in vitro tests (DPPH and ABTS) were also used to assess the extract's ability to sequester free radicals of 70% hydroethanolic and aqueous extracts of cubiu flour. Alkaloids, organic acids, phenols, flavonoid glycosides, and coumarins were found in the hydroethanolic extract while the aqueous extract presented anthocyanins, gums, tannins and mucilage, amino groups, and volatile and fixed acids. For in vitro tests, the IC50 value obtained in the DPPH assay was 606.3 +/- 3.5 mug/mL while that for the ABTS assay was 290.3 +/- 10.7 microg/mL. Although cubiu extracts present chemical compounds directly related to antioxidant activity, our results show that it has a low antioxidant activity. Additional studies will be needed to isolate and characterize specific compounds to further assess antioxidant activity"
Keywords:
Notes:		"PubMed-not-MEDLINEMascato, Diego Rocha de Lucena Herrera Monteiro, Janice B Passarinho, Michele M Galeno, Denise Morais Lopes Cruz, Ruben J Ortiz, Carmen Morales, Luisa Lima, Emerson Silva Carvalho, Rosany Piccolotto eng G12 MD007579/MD/NIMHD NIH HHS/ R25 GM082406/GM/NIGMS NIH HHS/ U54 MD007587/MD/NIMHD NIH HHS/ 2016/01/21 J Nutr Metab. 2015; 2015:364185. doi: 10.1155/2015/364185. Epub 2015 Dec 15"