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J Expo Sci Environ Epidemiol

Title:		Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Author(s):		Manz KE; Feerick A; Braun JM; Feng YL; Hall A; Koelmel J; Manzano C; Newton SR; Pennell KD; Place BJ; Godri Pollitt KJ; Prasse C; Young JA;
Address:		"School of Engineering, Brown University, Providence, RI, 02912, USA. katherine_manz@brown.edu. Agricultural & Environmental Chemistry Graduate Group, University of California, Davis, Davis, CA, 95616, USA. Department of Epidemiology, Brown University, Providence, RI, 02912, USA. Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada. Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, 06520, USA. Department of Chemistry, Faculty of Science, University of Chile, Santiago, RM, Chile. School of Public Health, San Diego State University, San Diego, CA, USA. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA. School of Engineering, Brown University, Providence, RI, 02912, USA. National Institute of Standards and Technology, 100 Bureau Dr, Gaithersburg, MD, 20899, USA. Department of Environmental Health & Engineering, Johns Hopkins University, Baltimore, MD, 21205, USA. Risk Sciences and Public Policy Institute, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA. Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, 20993, USA"
Journal Title:		J Expo Sci Environ Epidemiol
Year:		2023
Volume:		20230628
Issue:		4
Page Number:		524 - 536
DOI:		10.1038/s41370-023-00574-6
ISSN/ISBN:		1559-064X (Electronic) 1559-0631 (Print) 1559-0631 (Linking)
Abstract:		"Non-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques that rely on high-resolution mass spectrometry (HRMS) and computational tools to detect and identify unknown or suspected chemicals in the exposome. Fully understanding the chemical exposome requires characterization of both environmental media and human specimens. As such, we conducted a review to examine the use of different NTA and SSA methods in various exposure media and human samples, including the results and chemicals detected. The literature review was conducted by searching literature databases, such as PubMed and Web of Science, for keywords, such as 'non-targeted analysis', 'suspect screening analysis' and the exposure media. Sources of human exposure to environmental chemicals discussed in this review include water, air, soil/sediment, dust, and food and consumer products. The use of NTA for exposure discovery in human biospecimen is also reviewed. The chemical space that has been captured using NTA varies by media analyzed and analytical platform. In each media the chemicals that were frequently detected using NTA were: per- and polyfluoroalkyl substances (PFAS) and pharmaceuticals in water, pesticides and polyaromatic hydrocarbons (PAHs) in soil and sediment, volatile and semi-volatile organic compounds in air, flame retardants in dust, plasticizers in consumer products, and plasticizers, pesticides, and halogenated compounds in human samples. Some studies reviewed herein used both liquid chromatography (LC) and gas chromatography (GC) HRMS to increase the detected chemical space (16%); however, the majority (51%) only used LC-HRMS and fewer used GC-HRMS (32%). Finally, we identify knowledge and technology gaps that must be overcome to fully assess potential chemical exposures using NTA. Understanding the chemical space is essential to identifying and prioritizing gaps in our understanding of exposure sources and prior exposures. IMPACT STATEMENT: This review examines the results and chemicals detected by analyzing exposure media and human samples using high-resolution mass spectrometry based non-targeted analysis (NTA) and suspect screening analysis (SSA)"
Keywords:		Humans *Environmental Pollutants/analysis *Exposome Plasticizers/analysis Soil Dust/analysis Water/analysis Chemical space Environmental media Exposome High-resolution mass spectrometry Non-targeted analysis Suspect screening analysis;
Notes:		"MedlineManz, Katherine E Feerick, Anna Braun, Joseph M Feng, Yong-Lai Hall, Amber Koelmel, Jeremy Manzano, Carlos Newton, Seth R Pennell, Kurt D Place, Benjamin J Godri Pollitt, Krystal J Prasse, Carsten Young, Joshua A eng Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review 2023/06/29 J Expo Sci Environ Epidemiol. 2023 Jul; 33(4):524-536. doi: 10.1038/s41370-023-00574-6. Epub 2023 Jun 28"