| Title: | Breath indeed carries significant information about a disease: Potential biomarkers of cerebral palsy |
| Author(s): | Maiti KS; Roy S; Lampe R; Apolonski A; |
| Address: | "Max Planck Institute of Quantum Optics, Garching, Germany. Physics Department, Ludwig Maximilian University of Munich, Garching, Germany. Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Orthopaedic Department, Research Unit of the Buhl Strohmaier Foundation for Cerebral Palsy and Paediatric Neuroorthopaedics, Munich, Germany. Markus Wurth Professorship, Technical University of Munich, Munich, Germany. Physics Department, Novosibirsk State University, Novosibirsk, Russia. Institute of Automation and Electrometry SB RAS, Novosibirsk, Russia" |
| ISSN/ISBN: | 1864-0648 (Electronic) 1864-063X (Linking) |
| Abstract: | "Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P-value below 10(-5) . Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain-related disorder via breath, in this case CP" |
| Keywords: | Biomarkers Breath Tests *Cerebral Palsy/diagnosis Humans Spectrum Analysis *Volatile Organic Compounds breath cerebral palsy mid-infrared spectroscopy noninvasive medical diagnostics propionic acid esters; |
| Notes: | "MedlineMaiti, Kiran Sankar Roy, Susmita Lampe, Renee Apolonski, Alexander eng Research Support, Non-U.S. Gov't Germany 2020/06/12 J Biophotonics. 2020 Nov; 13(11):e202000125. doi: 10.1002/jbio.202000125. Epub 2020 Aug 17" |
