|
J Hematol Oncol
| Title: | A novel non-invasive exhaled breath biopsy for the diagnosis and screening of breast cancer |
|
| Author(s): | Liu J; Chen H; Li Y; Fang Y; Guo Y; Li S; Xu J; Jia Z; Zou J; Liu G; Xu H; Wang T; Wang D; Jiang Y; Wang Y; Tang X; Qiao G; Zhou Y; Bai L; Zhou R; Lu C; Wen H; Li J; Huang Y; Zhang S; Feng Y; Chen H; Xu S; Zhang B; Liu Z; Wang X; |
|
| Address: | "Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. State Key Laboratory of Molecular Oncology, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. Breax Laboratory, PCAB Research Center of Breath and Metabolism, Beijing, 100071, People's Republic of China. Department of Breast Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, People's Republic of China. Department of Breast Surgery, Guiyang Maternal and Child Healthcare Hospital, Guiyang, 550001, People's Republic of China. Department of Breast Surgery, Yanqing Maternal and Child Healthcare Hospital of Beijing, Beijing, 101399, People's Republic of China. Department of Radiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China. Department of Breast Surgery, Daxing Maternal and Child Healthcare Hospital of Beijing, Beijing, 100162, People's Republic of China. Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100005, People's Republic of China. Department of Neurosurgery, Xuanwu Hospital, China International Neuroscience Institute, National Center for Neurological Disorders, Capital Medical University, Beijing, 100053, People's Republic of China. Department of Breast Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050019, Hebei, People's Republic of China. Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, People's Republic of China. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. bailin_zhang@cicams.ac.cn. State Key Laboratory of Molecular Oncology, National Cancer Center /National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. liuzh@cicams.ac.cn. Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang, Beijing, 100021, People's Republic of China. xiangw@vip.sina.com" |
|
| Journal Title: | J Hematol Oncol |
| Year: | 2023 |
| Volume: | 20230616 |
| Issue: | 1 |
| Page Number: | 63 - |
| DOI: | 10.1186/s13045-023-01459-9 |
|
| ISSN/ISBN: | 1756-8722 (Electronic) 1756-8722 (Linking) |
|
| Abstract: | "BACKGROUND: Early detection is critical for improving the survival of breast cancer (BC) patients. Exhaled breath testing as a non-invasive technique might help to improve BC detection. However, the breath test accuracy for BC diagnosis is unclear. METHODS: This multi-center cohort study consecutively recruited 5047 women from four areas of China who underwent BC screening. Breath samples were collected through standardized breath collection procedures. Volatile organic compound (VOC) markers were identified from a high-throughput breathomics analysis by the high-pressure photon ionization-time-of-flight mass spectrometry (HPPI-TOFMS). Diagnostic models were constructed using the random forest algorithm in the discovery cohort and tested in three external validation cohorts. RESULTS: A total of 465 (9.21%) participants were identified with BC. Ten optimal VOC markers were identified to distinguish the breath samples of BC patients from those of non-cancer women. A diagnostic model (BreathBC) consisting of 10 optimal VOC markers showed an area under the curve (AUC) of 0.87 in external validation cohorts. BreathBC-Plus, which combined 10 VOC markers with risk factors, achieved better performance (AUC = 0.94 in the external validation cohorts), superior to that of mammography and ultrasound. Overall, the BreathBC-Plus detection rates were 96.97% for ductal carcinoma in situ, 85.06%, 90.00%, 88.24%, and 100% for stages I, II, III, and IV BC, respectively, with a specificity of 87.70% in the external validation cohorts. CONCLUSIONS: This is the largest study on breath tests to date. Considering the easy-to-perform procedure and high accuracy, these findings exemplify the potential applicability of breath tests in BC screening" |
|
| Keywords: | Humans Female *Breast Neoplasms/diagnosis *Volatile Organic Compounds/analysis Cohort Studies Early Detection of Cancer/methods Breath Tests/methods Biopsy Breast cancer Breath test Cancer screening Early diagnosis Volatile organic compound;neuroscience; |
|
| Notes: | "MedlineLiu, Jiaqi Chen, Haibin Li, Yalun Fang, Yanman Guo, Yang Li, Shuangquan Xu, Juan Jia, Ziqi Zou, Jiali Liu, Gang Xu, Hengyi Wang, Tao Wang, Dingyuan Jiang, Yiwen Wang, Yang Tang, Xuejie Qiao, Guangdong Zhou, Yeqing Bai, Lan Zhou, Ran Lu, Can Wen, Hongwei Li, Jiayi Huang, Yansong Zhang, Shuo Feng, Yong Chen, Hongyan Xu, Shouping Zhang, Bailin Liu, Zhihua Wang, Xiang eng LC2020B05/Beijing Hope Run Special Fund/ 82272938/National Natural Science Foundation of China/ 20220484059/Beijing Nova Program/ 2021-I2M-1-014 and 2021-I2M-C&T-A-015/CAMS Innovation Fund for Medical Sciences/ Letter Multicenter Study England 2023/06/17 J Hematol Oncol. 2023 Jun 16; 16(1):63. doi: 10.1186/s13045-023-01459-9" |
|
|
|
|
