| Title: | Feasibility and diagnostic accuracy of an electronic nose in children with asthma and cystic fibrosis |
| Author(s): | Bannier M; van de Kant KDG; Jobsis Q; Dompeling E; |
| Address: | "Department of Paediatric Respiratory Medicine, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre+, Maastricht, The Netherlands" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "The measurement of volatile organic compounds (VOCs) in exhaled breath is a promising tool for diagnosing and monitoring various lung diseases in children. Gas chromatography mass spectrometry (GC-MS) analysis is a frequently used standard technique for VOCs analysis. However, as GC-MS is an expensive and time-consuming technique, hand-held devices or electronic noses have been developed. Recently, the Aeonose was introduced as an easy-to-use hand-held eNose capable of point-of-care testing. Although first results using this eNose in adults are promising, studies in children are lacking. We therefore performed a cross-sectional study in 55 children and adolescents >/=6 years of age (20 children with moderate to severe asthma, 13 children with CF, and 22 healthy controls). The feasibility of the Aeonose was high (>98% successful measurements). The diagnostic accuracy was high for discriminating asthma from CF (Area Under the Receiver Operating Characteristic Curve [AUC] 0.90 [95% Confidence Interval 0.78-1.00] sensitivity 89% [65%-98%], specificity 77% [46%-94%]), and for the distinction between CF and healthy controls (AUC 0.87 [0.74-1.00], sensitivity 85% [54%-97%], specificity 77% [54%-91%]). However, the diagnostic accuracy for the discrimination between asthma and healthy controls was modest (AUC 0.79 [0.63-0.94], sensitivity 74% [49%-90%], specificity 91% [69%-98%]). This is the first study to report test results of the Aeonose in children and adolescents >/=6 years. This eNose showed a high feasibility with modest to good diagnostic accuracies in asthma and CF. This study was registered at clinicaltrial.gov (NCT03377686)" |
| Keywords: | Adolescent Asthma/*diagnosis Breath Tests/methods Case-Control Studies Child Cross-Sectional Studies Cystic Fibrosis/*diagnosis *Electronic Nose Exhalation Feasibility Studies Female Humans Male ROC Curve Volatile Organic Compounds/analysis; |
| Notes: | "MedlineBannier, Michiel A G E van de Kant, Kim D G Jobsis, Quirijn Dompeling, Edward eng Research Support, Non-U.S. Gov't England 2018/09/15 J Breath Res. 2019 May 8; 13(3):036009. doi: 10.1088/1752-7163/aae158" |
